Tissue Inflammatory Response in Subacute Sclerosing Panencephalitis (SSPE)

Anlar, Banu; Söylemezoglu, Figen; Aysun, Sabiha; Köse, Gülsen; Belen, Deniz; Yalaz, Kalbiye
December 2001
Journal of Child Neurology;Dec2001, Vol. 16 Issue 12, p895
Academic Journal
The pattern of inflammatory infiltration was studied in the frontal brain biopsies of 28 cases with subacute sclerosing panencephalitis (SSPE) by immunohistochemistry. Lymphocytic infiltration and gliosis were common pathologic findings. CD4+ Tlymphocytes were often observed in perivascular areas and CD8+ lymphocytes in the parenchyma. B lymphocytes were located in large perivascular cuffs associated with longer and slower disease. Major histocompatibility complex antigens, interferon-γ and tumor necrosis factor-α (TNF-α) were expressed in endothelial and glial cells. The inflammatory lesions in subacute sclerosing panencephalitis consist of various cell subtypes and cytokines localized in particular areas of the brain tissue and show certain associations with clinical course. (J Child Neurol 2001;16:895–900).


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