Rasburicase: Clearing Uric Acid from the Tumor Lysis Syndrome

Ershler, William B.
March 2011
Clinical Oncology Alert;Mar2011, Vol. 27 Issue 3, p19
The article discusses the safety and efficacy of using rasburicase (recombinant urate oxidase) for clearing uric acid in patients at high risk for tumor lysis syndrome (TLS) and children with leukemia and lymphoma. Pediatric and adult trials supporting the U.S. Food and Drug Administration's (FDA's) approval for such treatments are presented. Also discussed is the inclusion of rasburicase in the TLS treatment guidelines, its recommended dose and other critical factors affecting hyperuricemia.


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