TITLE

A review of mathematical models of influenza A infections within a host or cell culture: lessons learned and challenges ahead

AUTHOR(S)
Beauchemin, Catherine A. A.; Handel, Andreas
PUB. DATE
January 2011
SOURCE
BMC Public Health;2011 Supplement 1, Vol. 11 Issue Suppl 1, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Most mathematical models used to study the dynamics of influenza A have thus far focused on the between-host population level, with the aim to inform public health decisions regarding issues such as drug and social distancing intervention strategies, antiviral stockpiling or vaccine distribution. Here, we investigate mathematical modeling of influenza infection spread at a different scale; namely that occurring within an individual host or a cell culture. We review the models that have been developed in the last decades and discuss their contributions to our understanding of the dynamics of influenza infections. We review kinetic parameters (e.g., viral clearance rate, lifespan of infected cells) and values obtained through fitting mathematical models, and contrast them with values obtained directly from experiments. We explore the symbiotic role of mathematical models and experimental assays in improving our quantitative understanding of influenza infection dynamics. We also discuss the challenges in developing better, more comprehensive models for the course of influenza infections within a host or cell culture. Finally, we explain the contributions of such modeling efforts to important public health issues, and suggest future modeling studies that can help to address additional questions relevant to public health.
ACCESSION #
59334864

 

Related Articles

  • INFLUENCA: AKTUELAN MEDICINSKI PROBLEM. Bojić, Ívanko; Dulović, Olga; Gvozdenović, Eleonora; Minić, Svetlana // Medicinski Pregled / Medical Review;2007, Vol. 60 Issue 7/8, p351 

    Introduction: Acute respiratory infections are the most common infections in the human population. Among them, virus infections, especially those caused by influenza viruses, have an important place. Type A influenza: Type A influenza virus caused three epidemics during the last century. A high...

  • Conserved epitopes of influenza A virus inducing protective immunity and their prospects for universal vaccine development. Staneková, Zuzana; Varecková, Eva // Virology Journal;2010, Vol. 7, p351 

    Influenza A viruses belong to the best studied viruses, however no effective prevention against influenza infection has been developed. The emerging of still new escape variants of influenza A viruses causing epidemics and periodic worldwide pandemics represents a threat for human population....

  • Oseltamivir-resistant influenza.  // Critical Care Alert;May2009 Clinical Briefs in Primary, p9 

    The article reports on the resistance of Oseltamivir (OSTV) to Influenza A, It says that sentinel physicians in the U.S. found that OSTV resistance profiles have changed dramatically when administered to patients with Influenza A virus.

  • Mathematical Modeling of the Effectiveness of Facemasks in Reducing the Spread of Novel Influenza A (H1N1). Tracht, Samantha M.; Valle, Sara Y. Del; Hyman, James M. // PLoS ONE;2010, Vol. 5 Issue 2, p1 

    On June 11, 2009, the World Health Organization declared the outbreak of novel influenza A (H1N1) a pandemic. With limited supplies of antivirals and vaccines, countries and individuals are looking at other ways to reduce the spread of pandemic (H1N1) 2009, particularly options that are cost...

  • Influenza Activity -- United States and Worldwide, 2007-08 Season.  // MMWR: Morbidity & Mortality Weekly Report;6/27/2008, Vol. 57 Issue 25, p692 

    The article reports on the influenza activity in the U.S. and other parts of the world from 2007 to 2008. The viral surveillance results reportedly show more cases of influenza A viruses than influenza B in all surveillance regions. Information on various important concerns like resistance to...

  • Highly Pathogenic Avian Influenza A (H7N3) Virus Infection in Two Poultry Workers -- Jalisco, Mexico, July 2012. Barrera-Badillo, Gisela; Ramirez-Gonzalez, Ernesto; Aparicio-Antonio, Rodrigo; Nuñez-Garcia, Tatiana; Arellano-Suarez, Dayanira; Alcantara-Perez, Patricia; Rodriguez-Maldonado, Abril; Rodriguez-Reyes, Brisia; Wong-Arambula, Claudia; Gonzalez-Duran, Elizabeth; Ortiz-Alcantara, Joanna; Diaz-Quiñonez, Alberto; Lopez-Martinez, Irma; Reyes-Teran, Gustavo; Vazquez-Perez, Joel; Avila-Rios, Santiago; Robles-Cruz, Armando; Montoya-Fuentes, Hector; Borja-Aburto, Victor; Ruiz-Matus, Cuit // MMWR: Morbidity & Mortality Weekly Report;9/14/2012, Vol. 61 Issue 36, p726 

    The article describes two cases of patients who were diagnosed with conjunctivitis without fever or respiratory symptoms due to highly pathogenic avian influenza A (H7N3) virus infection. Both patients were exposed to infected poultry. One of the patients, a 32-year-old poultry worker,...

  • Mathematical Modeling of Influenza A Virus Dynamics within Swine Farms and the Effects of Vaccination. Reynolds, Jennifer J. H.; Torremorell, Montserrat; Craft, Meggan E. // PLoS ONE;Aug2014, Vol. 9 Issue 8, p1 

    Influenza A virus infections are widespread in swine herds across the world. Influenza negatively affects swine health and production, and represents a significant threat to public health due to the risk of zoonotic infections. Swine herds can act as reservoirs for potentially pandemic influenza...

  • Suggestions to the media to help us cope with the A/H7N9 crisis in China. Yang Sun; Hongzhou Lu // Drug Discoveries & Therapeutics;Apr2014, Vol. 8 Issue 2, p100 

    The A/H7N9 avian influenza virus sparked global concerns about public health. The media published numerous reports about emerging infectious diseases, including their clinical characteristics and genomic information. However, outbreaks of A/H7N9 posed a real challenge to China's emergency...

  • How to win trust over flu.  // Nature;10/8/2009, Vol. 461 Issue 7265, p698 

    The author reflects on a poll by the Harvard School of Public Health in Boston, Massachusetts regarding a mass-vaccination campaign against the pandemic outbreak of H1N1 virus. He discusses the result of the survey that indicates public hesitance to get vaccinated wherein out of ten U.S. adults,...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics