Diabetes mellitus and genetically programmed defects in Beta-cell function

Bell, Graeme I.; Polonsky, Kenneth S.
December 2001
Nature;12/13/2001, Vol. 414 Issue 6865, p788
Academic Journal
Focuses on diabetes mellitus and genetically programmed defects in Beta-cell function. Description of diabetes mellitus; Determinants of insulin concentrations; Genetic deficiencies in insulin secretion.


Related Articles

  • Mechanisms of glucose hypersensitivity in beta-cells from normoglycemic, partially pancreatectomized mice. Martin, Franz; Andreu, Etelvina; Revira, Juan Manuel; Pertusa, Jose A.G.; Raurell, Merce; Ripoll, Cristina; Sanchez-Andres, Juan Vicente; Montanya, Eduard; Soria, Bernat // Diabetes;Oct99, Vol. 48 Issue 10, p1954 

    Studies the ionic mechanisms responsible for increased beta-cell glucose sensitivity in diabetic mice. Association of increased beta-cell glucose sensitivity to insulin secretion; Effect of pancreatectomy on glucose-induced insulin secretion, membrane potential and intracellular calcium;...

  • CELL ENGINEERING MAY HELP CONTROL DIABETES. Moore, Amy Slugg // RN;Apr2000, Vol. 63 Issue 4, p104 

    Focuses on a method developed by researchers for triggering the secretion of insulin in diabetics.

  • Role of residual insulin secretion in protecting against ketoacidosis in insulin-dependent diabetes. Madsbad, Sten; Alberti, K. George M.M.; Binder, Christian; Burrin, Jackie M.; Faber, Ole K.; Krarup, Thure // British Medical Journal;11/17/1979, Vol. 2 Issue 6200, p1257 

    Examines the role of residual insulin secretion in protecting against ketoacidosis in insulin-dependent diabetes. Determination of beta cells function from C-peptide concentrations; Reduction of blood glucose concentrations; Importance of residual secretion in diabetes.

  • Geriatric medicine.  // Clinical & Investigative Medicine;Aug97 Supplement, Vol. 20, pS27 

    Presents an abstract of the research manuscript `Role of first phase insulin release in the pathogenesis of diabetes in the elderly,' by J. Kwok, T. Elliott et al from the University of British Columbia.

  • Insulin secretion in diabetes mellitus. Kipnis, David M.; Kipnis, D M // Annals of Internal Medicine;Nov68, Vol. 69 Issue 5, p891 

    Deals with a study on the normal physiological mechanisms regulating insulin release from pancreas and characterizes the changes in insulin secretion associated with various clinical forms of diabetes mellitus. Plasma insulin responses to oral and infused glucose; Biologic effectiveness of...

  • Effects of Nonglucose Nutrients on Insulin Secretion and Action in People With Pre-Diabetes. Bock, Gerlies; Man, Chiara Dalla; Campioni, Marco; Chittilapilly, Elizabeth; Basu, Rita; Toffolo, Gianna; Cobelli, Claudio; Rizza, Robert // Diabetes;Apr2007, Vol. 56 Issue 4, p1113 

    To determine whether nonglucose nutrient-induced insulin secretion is impaired in pre-diabetes, subjects with impaired or normal fasting glucose were studied after ingesting either a mixed meal containing 75 g glucose or 75 g glucose alone. Despite comparable glucose areas above basal,...

  • Pulsatile Insulin Release From Islets Isolated From Three Subjects With Type 2 Diabetes.  // Diabetes;Apr2002, Vol. 51 Issue 4, p988 

    Examines the dynamics of insulin release from islets isolated from three subjects with type 2 diabetes. Implication on the development of insulin resistance; Increment of insulin release; Relation between impaired secretory response to glucose and impaired metabolism.

  • Phasic insulin release and metabolic regulation in type 2 diabetes. Del Prato, Stefano; Marchetti, Piers; Bonadonna, Riecardo C.; Marchetti, Piero; Bonadonna, Riccardo C // Diabetes;Feb2002 Supplement, Vol. 51, pS109 

    Type 2 diabetes is a heterogeneous disorder due to prevalent insulin resistance associated with deficient insulin secretion or to a prevalent defect of insulin secretion associated with impaired insulin action. The definition is supported by the high frequency at which insulin resistance can be...

  • Insulin: A Never-ending Evolution. Dinsmoor, Robert S. // Countdown;Spring2001, Vol. 22 Issue 2, p46 

    Focuses on insulin, a protein used to treat diabetes. History of insulin and how it's relationship with glucose; Way that insulin works in the body; Technological advances made in insulin research; Details of insulin analogs; Efforts of manufacturers to explore alternative methods for...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics