TITLE

Joint immobilization inhibits spontaneous hyaline cartilage regeneration induced by a novel double-network gel implantation

AUTHOR(S)
Arakaki, Kazunobu; Kitamura, Nobuto; Kurokawa, Takayuki; Onodera, Shin; Kanaya, Fuminori; Jian-Ping Gong; Yasuda, Kazunori
PUB. DATE
February 2011
SOURCE
Journal of Materials Science: Materials in Medicine;Feb2011, Vol. 22 Issue 2, p417
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We have recently discovered that spontaneous hyaline cartilage regeneration can be induced in an osteochondral defect in the rabbit, when we implant a novel double-network (DN) gel plug at the bottom of the defect. To clarify whether joint immobilization inhibits the spontaneous hyaline cartilage regeneration, we conducted this study with 20 rabbits. At 4 or 12 weeks after surgery, the defect in the mobile knees was filled with a sufficient volume of the hyaline cartilage tissue rich in proteoglycan and type-2 collagen, while no cartilage tissues were observed in the defect in the immobilized knees. Type-2 collagen, Aggrecan, and SOX9 mRNAs were expressed only in the mobile knees at each period. This study demonstrated that joint immobilization significantly inhibits the spontaneous hyaline cartilage regeneration induced by the DN gel implantation. This fact suggested that the mechanical environment is one of the significant factors to induce this phenomenon.
ACCESSION #
59317208

 

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