TITLE

Human papillomavirus genotypes distribution in cervical samples from women living with human immunodeficiency virus

AUTHOR(S)
Melgaço, Fabiana; Rosa, Maria; Augusto, Everton; Haimuri, Jacqueline; Jacintho, Claudia; Santos, Larissa; Cavalcanti, Silvia; Oliveira, Ledy
PUB. DATE
April 2011
SOURCE
Archives of Gynecology & Obstetrics;Apr2011, Vol. 283 Issue 4, p809
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The aim of this study was to determine the prevalence and relationship of human papillomavirus (HPV) genotypes in cervical samples from 140 human immunodeficiency virus (HIV)-seropositive women routinely attending an outpatient public gynecological service in the state of Rio de Janeiro, Brazil. Methods: MY09/11 consensus primers were used to detect generic HPV DNA. HPV typification was performed by restriction fragment length polymorphism analysis following polymerase chain reaction amplification. Results: The overall HPV prevalence was 60.0%. The identification of 24 different HPV genotypes including uncommon types was performed. A9 oncogenic genotypes were present in 54.02% of HIV-positive women. Abnormal cervical lesions, the time since HIV diagnosis and the number of sexual partners contributed independently to the high oncogenic HPV prevalence. The oncogenic and non-oncogenic group were similarly affected by risk factors in contrast to negative HPV women. The frequency of multiple infections was 20%; furthermore, all of them presented at least one oncogenic type. Conclusion: The analyzed sample represents an epidemiological source of uncommon infection. Due to high HPV prevalence, more frequent cytological screening and/or liberal colposcopic evaluations should be performed in HIV-positive patients.
ACCESSION #
59259656

 

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