TITLE

CHIRAL DRUG ANALYSIS AND THEIR APPLICATION

AUTHOR(S)
Nagori, B. P.; Deora, M. S.; Saraswat, P.
PUB. DATE
January 2011
SOURCE
International Journal of Pharmaceutical Sciences Review & Resear;Jan/Feb2011, Vol. 6 Issue 2, p106
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The biological activity of chiral substances often depends upon their stereochemistry, since the living body is a highly chiral environment. A large percentage of commercial and investigational pharmaceutical compounds are enantiomers, and many of them show significant enantioselective differences in their pharmacokinetics and pharmacodynamics. Two main approaches to chiral drug analysis have been taken. In the so-called indirect approach, the drug enantiomers are derivatized with an optically pure chiral reagent to form a pair of diastereomers, which may then have sufficiently different physiochemical properties for separation to occur on conventional chromatographic columns. In the direct approach, transient rather than covalent diastereomeric complexes are formed between the drug enantiomers and a chiral selector present either in the mobile or the stationary chromatographic phase. In the current context there is looking for advances stationary phases like Whelk-O® 1, Leucine, 3-Gem 1, Pirkle 1-J, DACH-DNB, ULMO, Chiral AGP, Chiral CBH, Chiral HAS, CHIRALPAK IA, NUCLEOCEL DELTA, CHIROBIOTIC, macrocycolic glycopeptides phases etc. Chiral analysis of biomolecules like amino acids, sugars, proteins, lipid and nucleic acids are interesting feature of these chiral biomolecules is that in nature they usually exist in only one of the two possible enantiomeric forms. Along with this other important application of chiral drugs analysis are therapeutic drug monitoring, in clinical and forensic toxicology and chiral specific applications of essential oils, flavors, and pharmaceutical drugs.
ACCESSION #
59247804

 

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