Strategies for Enhancing the Performance of Cleaning Processes Part I-A Framework for Assessing Performance

Sharnez, Rizwan; Monk, Michelle
February 2011
Journal of Validation Technology;Winter2011, Vol. 17 Issue 1, p36
Academic Journal
The article describes the methodologies involved in the performance of cleaning processes the performance of cleaning processes. It demonstrates the development and application of experimental models to assess and enhance performance. Among the factors that determine cleaning performance are equipment, soil, cleaning agent, and operating parameters. It was concluded that cleaning the worst-case location (WCL) within a specified time may also clean the entire system within that time. The WCL refers to an area within the equipment which has poor circulation and this can be a dead leg, or a shadowed area, like the underside of an impeller shaft or blade, or a magnetically coupled bottom-mounted impeller.


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