TITLE

Ozone as U-Shaped Dose Responses Molecules (Hormetins)

AUTHOR(S)
Martínez-Sánchez, G.; Pérez-Davison, G.; Re, L.; Giuliani, A.
PUB. DATE
January 2011
SOURCE
Dose-Response;2011, Vol. 9 Issue 1, p32
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Redox environment involves a broad network of pro-oxidant and antioxidant components. Health benefit or damage can be induced as a consequence of an adaptive cellular stress response. A consequence of hormetic amplification is an increase in the homeodynamic space of a living system in terms of an increased defense capacity and a reduced load of damaged macromolecules. Ozone, when used at appropriate doses, promotes the formation of reactive oxygen species and lipid peroxides allows them to become late and long-lasting messengers. Healthy aging may be achieved by hormesis through mild and periodic, but not severe or chronic, physical and mental challenges, and by the use of nutritional hormesis incorporating mild stress-inducing molecules called hormetins. The paradoxical concept that ozone eventually induces an antioxidant response capable of reversing a chronic oxidative stress is common in the animal and vegetal kingdom; it is already supported by findings of an increased level of antioxidant enzymes during ozone therapy. Those facts can include ozone as a hormetin. The established scientific foundations of hormesis are ready to pave the way for new and effective approaches in redox-related disease research and intervention; ozone therapy can be a good candidate.
ACCESSION #
59192608

 

Related Articles

  • Low-Dose Cancer Risk Modeling Must Recognize Up-Regulation of Protection. Feinendegen, Ludwig E.; Pollycove, Myron; Neumann, Ronald D. // Dose-Response;2010, Vol. 8 Issue 2, p227 

    Ionizing radiation primarily perturbs the basic molecular level proportional to dose, with potential damage propagation to higher levels: cells, tissues, organs, and whole body. There are three types of defenses against damage propagation. These operate deterministically and below a certain...

  • A MODEL OF CYTOTOXIC DOSE-RESPONSE NONLINEARITIES ARISING FROM ADAPTIVE CELL INVENTORY MANAGEMENT IN TISSUES. Cox Jr., Louis Anthony (Tony) // Dose-Response;2005, Vol. 3 Issue 4, p491 

    Why do low-level exposures to environmental toxins often elicit over-compensating responses that reduce risk to an organism? Conversely, if these responses improve health, why wait for an environmental challenge to trigger them? This paper presents a mathematical modeling framework that...

  • Radiation hormesis: its historical foundations as a biological hypothesis. Calabrese, E.J.; Baldwin, L.A. // Human & Experimental Toxicology;Jan2000, Vol. 19 Issue 1, p41 

    This paper represents the first systematic effort to describe the historical foundations of radiation hormesis. Spanning the years from 1898 to the early 1940's the paper constructs and assesses the early history of such research and evaluates how advances in related scientific fields affected...

  • "Is Hormesis Applicable as a Pro-Healthy Aging Intervention in Mammals and Human Beings, and How?": Introduction to a Special Issue of Dose-Response. Le Bourg, Éric; Rattan, Suresh I. S. // Dose-Response;2010, Vol. 8 Issue 1, p1 

    No abstract available.

  • Hormesis and radiation safety norms. Jargin, SV // Human & Experimental Toxicology;Jul2012, Vol. 31 Issue 7, p671 

    Today's radiation safety norms are based on the linear no-threshold theory (LNT): extrapolation of the dose-response relationships down to the minimal doses, where such relationships are unproven and can be inverse due to hormesis. The most promising way to obtaining reliable data on the...

  • Low-Dose Nonlinear Effects of Smoking on Coronary Heart Disease Risk. Cox, Louis Anthony (Tony) // Dose-Response;2012, Vol. 10 Issue 2, p219 

    Some recent discussions of adverse human health effects of active and passive smoking have suggested that low levels of exposure are disproportionately dangerous, so that "The effects of even brief (minutes to hours) passive smoking are often nearly as large (averaging 80% to 90%) as chronic...

  • The Dose Window for Radiation-Induced Protective Adaptive Responses. Mitchel, Ronald E. J. // Dose-Response;2010, Vol. 8 Issue 2, p192 

    Adaptive responses to low doses of low LET radiation occur in all organisms thus far examined, from single cell lower eukaryotes to mammals. These responses reduce the deleterious consequences of DNA damaging events, including radiation-induced or spontaneous cancer and non-cancer diseases in...

  • The Healthy Worker Effect and Nuclear Industry Workers. Fornalski, Krzysztof W.; Dobrzyński, Ludwik // Dose-Response;2010, Vol. 8 Issue 2, p125 

    The linear no-threshold (LNT) dose-effect relationship has been consistently used by most radiation epidemiologists to estimate cancer mortality risk. The large scattering of data by International Agency for Research on Cancer, IARC (Vrijheid et al. 2007; Therry-Chef et al. 2007; Cardis et al....

  • Preface. Sykes, Pamela; Mitchel, Ron; Higson, Donald // Dose-Response;2007, Vol. 5 Issue 4, p256 

    A preface for the October 2007 issue of the "Dose-Response" is presented.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics