Epidemiological Evidence for Possible Radiation Hormesis from Radon Exposure: A Case-Control Study Conducted in Worcester, MA

Thompson, Richard E.
January 2011
Dose-Response;2011, Vol. 9 Issue 1, p59
Academic Journal
Data from a case-control study of lung cancer and residential radon exposure conducted in Worcester County, Massachusetts, are presented. Lung cancer risk was estimated using conditional logistic regression models that controlled for demographic, smoking, and occupational exposure covariates. Preliminary exploratory analyses using lowess smoothing revealed a non-linear association between exposure and the log odds of lung cancer. Radon exposure was considered by using linear spline terms in order to model this nonlinearity. The best fit of this linear spline model to these data predicted a shift from a positive to a negative slope in the log-odds of lung cancer at a radon concentration of 70 Bq m-3. A statistically significant decrease in cancer risk with increased exposure was found for values ≤ 157 Bq m-3 normalized to the reference exposure of 4.4 Bq m-3, the lowest radon concentration measured(adjusted odds ratio (AOR) [95% CI] = 0.42 [0.180, 1.00], p = 0.049). This result is consistent with those reported elsewhere that considered radon exposure with cubic spline terms (Thompson, RE et al. 2008). Furthermore, this model predicts an AOR that is numerically less than 1.0 for radon exposures up to 545 Bq m-3 versus the above baseline, reference exposure.


Related Articles

  • Aggregation of Lung Cancer in Families: Results from a Population-based Case-Control Study in Germany. Bromen, Katja; Pohlabeln, Hermann; Jahn, Ingeborg; Ahrens, Wolfgang; Jöckel, Karl-Heinz // American Journal of Epidemiology;Sep2000, Vol. 152 Issue 6, p497 

    The authors investigated familial aggregation of lung cancer by means of a population-based case-control study, conducted in Germany between 1988 and 1993. They compared lung cancer prevalence in first degree relatives of 945 patients and 983 controls, accounting for various potential risk...

  • Lack of a protective effect of cotton dust on risk of lung cancer: evidence from two population-based case-control studies. Christensen, Krista Yorita; Lavoué, Jérôme; Rousseau, Marie-Claude; Siemiatycki, Jack // BMC Cancer;2015, Vol. 15 Issue 1, p1 

    Background: Lung cancer is the leading cause of cancer death in North America. Exposure to cotton dust has previously been reported to decrease the risk of lung cancer. Methods: We used data from two large case-control studies conducted in Montreal from 1979-1986 (Study 1) and 1996-2002 (Study...

  • Dietary folate intake and the risk of 11 types of cancer: a case–control study in Uruguay. Aune, D.; Deneo-Pellegrini, H.; Ronco, A. L.; Boffetta, P.; Acosta, G.; Mendilaharsu, M.; De Stefani, E. // Annals of Oncology;Feb2011, Vol. 22 Issue 2, p444 

    Background: There is limited, but inconclusive, epidemiological evidence that high folate intake decreases the risk of colorectal and esophageal cancers. For other cancer sites, the evidence is even less consistent or extensive.Materials and methods: We conducted a case–control study of...

  • Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies. Zaitlen, Noah; Lindström, Sara; Pasaniuc, Bogdan; Cornelis, Marilyn; Genovese, Giulio; Pollack, Samuela; Barton, Anne; Bickeböller, Heike; Bowden, Donald W.; Eyre, Steve; Freedman, Barry I.; Friedman, David J.; Field, John K.; Groop, Leif; Haugen, Aage; Heinrich, Joachim; Henderson, Brian E.; Hicks, Pamela J.; Hocking, Lynne J.; Kolonel, Laurence N. // PLoS Genetics;Nov2012, Vol. 8 Issue 11, Special section p1 

    Genetic case-control association studies often include data on clinical covariates, such as body mass index (BMI), smoking status, or age, that may modify the underlying genetic risk of case or control samples. For example, in type 2 diabetes, odds ratios for established variants estimated from...

  • Pilot Study of CYP2B6 Genetic Variation to Explore the Contribution of Nitrosamine Activation to Lung Carcinogenesis. Wassenaar, Catherine A.; Dong, Qiong; Amos, Christopher I.; Spitz, Margaret R.; Tyndale, Rachel F. // International Journal of Molecular Sciences;Apr2013, Vol. 14 Issue 4, preceding p8381 

    We explored the contribution of nitrosamine metabolism to lung cancer in a pilot investigation of genetic variation in CYP2B6, a high-affinity enzymatic activator of tobacco-specific nitrosamines with a negligible role in nicotine metabolism. Previously we found that variation in CYP2A6 and...

  • Impact of occupational carcinogens on lung cancer risk in a general population. De Matteis, Sara; Consonni, Dario; Lubin, Jay H; Tucker, Margaret; Peters, Susan; Vermeulen, Roel CH; Kromhout, Hans; Bertazzi, Pier Alberto; Caporaso, Neil E; Pesatori, Angela C; Wacholder, Sholom; Landi, Maria Teresa // International Journal of Epidemiology;Jun2012, Vol. 41 Issue 3, p711 

    Background Exposure to occupational carcinogens is an important preventable cause of lung cancer. Most of the previous studies were in highly exposed industrial cohorts. Our aim was to quantify lung cancer burden attributable to occupational carcinogens in a general population.Methods We applied...

  • Lung cancer risk among workers in the construction industry: results from two case-control studies in Montreal. Lacour, Aude; Pintos, Javier; Lavoué, Jérôme; Richardson, Lesley; Siemiatycki, Jack; Lacourt, Aude // BMC Public Health;9/23/2015, Vol. 15 Issue 1, p1 

    Background: Given the large number of workers in the construction industry, it is important to derive accurate and valid estimates of cancer risk, and in particular lung cancer risk. In most previous studies, risks among construction workers were compared with general populations...

  • Radiothérapie en conditions stéréotaxiques des cancers bronchiques de stade I. Martel-Lafay, I. // Oncologie;May2012, Vol. 14 Issue 5, p282 

    Stereotactic body radiotherapy (SBRT) is an innovative irradiation technique which delivers high dose per fraction in a highly accurate way. It allows to treat medically inoperable patients with non-small cell lung cancer, with impressive local control rates and a very little toxicity. The...

  • The relationship between pulmonary function metrics and radiation-induced lung injury. Linam, Justin M.; Madtes, David; Chow, Laura; Liu, Karen; Schmidt, Rodney; Patel, Shilpen // Journal of Solid Tumors;Feb2013, Vol. 3 Issue 1, p6 

    Introduction: Radiation-induced lung injury (RILI) is a potentially fatal yet incompletely understood complication following radiation therapy. Models have been posited to predict RILI risk but have produced inconsistent results. Here we evaluate pulmonary function testing (PFT) metrics vs. RILI...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics