Modeling Dose-Response at Low Dose: A Systems Biology Approach for Ionization Radiation

Zhao, Yuchao; Ricci, Paolo F.
October 2010
Dose-Response;2010, Vol. 8 Issue 4, p456
Academic Journal
For ionization radiation (IR) induced cancer, a linear non-threshold (LNT) model at very low doses is the default used by a number of national and international organizations and in regulatory law. This default denies any positive benefit from any level of exposure. However, experimental observations and theoretical biology have found that both linear and J-shaped IR dose-response curves can exist at those very low doses. We develop low dose J-shaped dose-response, based on systems biology, and thus justify its use regarding exposure to IR. This approach incorporates detailed, molecular and cellular descriptions of biological/ toxicological mechanisms to develop a dose-response model through a set of nonlinear, differential equations describing the signaling pathways and biochemical mechanisms of cell cycle checkpoint, apoptosis, and tumor incidence due to IR. This approach yields a J-shaped dose response curve while showing where LNT behaviors are likely to occur. The results confirm the hypothesis of the J-shaped dose response curve: the main reason is that, at low-doses of IR, cells stimulate protective systems through a longer cell arrest time per unit of IR dose. We suggest that the policy implications of this approach are an increasingly correct way to deal with precautionary measures in public health.


Related Articles

  • Linear, no threshold response at low doses of ionizing radiation: ideology, prejudice and science. Kesavan, P. C. // Current Science (00113891);7/10/2014, Vol. 107 Issue 1, p46 

    The linear, no threshold (LNT) response model assumes that there is no threshold dose for the radiation-induced genetic effects (heritable mutations and cancer), and it forms the current basis for radiation protection standards for radiation workers and the general public. The LNT model is,...

  • Radiation exposure and adaptive processes. Mossman, K.L.; Ledesma, L.M. // Human & Experimental Toxicology;1999, Vol. 18 Issue 7, p436 

    Provides information on a study related to adaptive response and radiation exposure. Relation of the dose that induces the adaptive response to human and environmental exposures; Effects of inducing the adaptive response; Association of the adaptive response to the concept of hormesis.

  • Radioadaptive response: responses to the five questions. Ikushima, T. // Human & Experimental Toxicology;1999, Vol. 18 Issue 7, p433 

    Presents responses to several questions related to the adaptive response (AR) to ionizing radiation. Relevance of AR to human and environmental exposures; Analysis on whether the induction of AR can be manipulated for medical and other benefits; How does AR relate to the concept of hormesis.

  • Association Between Local External Gamma Rays and Frequency of Cancer in Babol-Iran. Monfared, Ali Shabestani; Hajian, Karimollah; Hosseini, Reza; Nasir, Akbar // Dose-Response;2010, Vol. 8 Issue 3, p368 

    Introduction: The effect of natural background radiation on Cancer is still challenging. The investigation of association between external gamma rays and Cancer was the main goal of study. Materials & Methods: External Gamma rays were measured using a radiation survey meter in 184 urban and...

  • Which DNA Damage is Likely to be Relevant in Hormetic Responses? Bernhard, William A.; Purkayastha, Shubhadeep; Milligan, Jamie R. // Dose-Response;2008, Vol. 6 Issue 2, p184 

    Working under the assumption that hormesis is triggered by specific types of DNA damage, this report focuses on the types of damage which form the signature of ionizing radiation. The key attribute of the signature is the clustering of damage, arising from clusters of energy deposition such that...

  • Summary and comments. Waldren, C.A. // Human & Experimental Toxicology;1999, Vol. 18 Issue 7, p452 

    Provides answers to several questions concerning adaptive response (AR) and hormesis elicited by ionizing radiation. How does the dose that induces AR relate to human and environmental exposure; Advantages and disadvantages of AR stimulation; Discussion on whether AR simulation can be...

  • The adaptive response to ionizing radiation: low dose effects unpredictable from high dose experiments. Rigaud, O. // Human & Experimental Toxicology;1999, Vol. 18 Issue 7, p443 

    Comments on several issues regarding adaptive response (AR) to ionizing radiation. Relevance of the dose that induces the AR to human and environmental exposures; Advantages and disadvantages of having induced AR; Issue on whether the induction of AR can be manipulated for medical and other...

  • Hormesis, an update of the present position. Johansson, Lennart // European Journal of Nuclear Medicine & Molecular Imaging;2003, Vol. 30 Issue 6, p921 

    The ongoing debate over the possible beneficial effects of ionising radiation on health, hormesis, is reviewed from different perspectives. Radiation hormesis has not been strictly defined in the scientific literature. It can be understood as a decrease in the risk of cancer due to low-dose...

  • Chest radiography doses with film screen: Is further reduction possible? Egbe, Nneoyi O.; Heaton, B.; Sharp, Peter F. // South African Radiographer;Nov2010, Vol. 48 Issue 2, p28 

    In order to establish the possibility and extent of further dose reduction in film screen chest radiography, gelatine based test objects were used in a simple chest phantom to obtain images at the current chest dose (Dref) and at percent dose reduction of 41, 65 and 77, respectively. Images...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics