Exercise-Induced Hormesis may Help Healthy Aging

Ji, Li Li; Dickman, Jonathan R.; Kang, Chounghun; Koenig, Ryan
January 2010
Dose-Response;2010, Vol. 8 Issue 1, p73
Academic Journal
Hormesis plays a critical role in producing some major benefits derived from physical exercise. However whether these known cellular mechanisms are applicable to ameliorate age-related deterioration of muscle function is not entirely clear. The present communication proposes that antioxidant adaptation, the peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α activated mitochondrial biogenesis, and eccentric contraction-induced, cytokine-propelled muscle inflammation could be important redox-sensitive pathways by which exercise-induced disturbance in oxidant-antioxidant hemeostasis may serve as a heretic stimulus to promote adaptations that help healthy aging and improve the quality of life.


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