Hormesis as a Pro-Healthy Aging Intervention in Human Beings?
- Resveratrol mechanism revealed. DeFrancesco, Laura // Nature Biotechnology;Mar2012, Vol. 30 Issue 3, p251
The article reports on the relationship between resveratrol and longevity, in which resveratrol is said to activate SirtI, a type of sirtuin acetylases that is said to be central in mediating the health benefits of caloric restriction.
- Evolution of Human Longevity Uncoupled from Caloric Restriction Mechanisms. Zhao, Guodong; Guo, Song; Somel, Mehmet; Khaitovich, Philipp // PLoS ONE;Jan2014, Vol. 9 Issue 1, p1
Caloric restriction (CR) and chemical agents, such as resveratrol and rapamycin that partially mimic the CR effect, can delay morbidity and mortality across a broad range of species. In humans, however, the effects of CR or other life-extending agents have not yet been investigated...
- Hormesis: a quest for virtuality? Toussaint, O.; Remacle, J.; Dierick, J-F.; Pascal, T.; Frippiat, C.; Magalhaes, J.P.; Chainaux, F. // Human & Experimental Toxicology;Jun2001, Vol. 20 Issue 6, p311
Addresses several questions related to hormesis and longevity. Use of the concept of hormesis in biogerontology; Difference between hormesis with possible positive effects on life span and stress-induced premature senescence; Arguments in favor of life span-prolonging effects of hormesis; Link...
- Multiple Pathways Regulating the Calorie Restriction Response in Yeast. Rahat, Ofer; Maoz, Noam; Cohen, Haim Y. // Journals of Gerontology Series A: Biological Sciences & Medical ;Feb2011, Vol. 66A Issue 2, p163
In yeast, SIR2 overexpression or calorie restriction (CR) results in life-span extension. It was previously suggested that CR activates Sir2 by reducing the levels of Sir2 inhibitors, NADH, or nicotinamide. Whereas NADH reduction is associated with an increase in respiration, nicotinamide...
- Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index. Kane, Alice E.; Hilmer, Sarah N.; Boyer, Dawn; Gavin, Kristan; Nines, Dawn; Howlett, Susan E.; de Cabo, Rafael; Mitchell, Sarah J. // Journals of Gerontology Series A: Biological Sciences & Medical ;Mar2016, Vol. 71 Issue 3, p333
This article investigates the effect on the mouse frailty index (FI), of factors known to influence lifespan and healthspan in mice: strain (short-lived DBA/2J mice vs long-lived C57BL/6J mice), calorie restriction (CR), and resveratrol treatment. The mouse FI, based on deficit accumulation, was...
- Gerontology: Eat your cake and have it. Spinney, Laura // Nature;6/15/2006, Vol. 441 Issue 7095, p807
The article features the relationship between the food intake and the aging, and longevity. It reports that the calorie restriction, below energy expenditure, can slow ageing, reduce diseases, and extend maximum lifespan in animals such as rats, mice, worms and yeast. Similarly, the study of...
- Obesity: Gaining SIRT-ainty. Levinson, Randy // Nature Medicine;Sep2012, Vol. 18 Issue 9, p1348
The article offers information regarding the importance of sertuin 1 protein as metabolic benefits of calorie restriction and for improving metabolic health.
- Response to the commentaries on “Does caloric restriction induce hormesis?”. Turturro, A.; Hass, B.S.; Hart, R.W. // Human & Experimental Toxicology;Jun2000, Vol. 19 Issue 6, p355
Responds to a comment on the role of caloric restriction in hormesis. Concerns raised about the concept of malnutrition; Inconsistencies in the definitions of the components of hormesis; Limitations of the Gompertzian analysis.
- Does caloric restriction cause hormesis? Comments on paper by Turturro, Hass and Hart. Wilson, R. // Human & Experimental Toxicology;Jun2000, Vol. 19 Issue 6, p353
Comments on an article about the role of caloric restriction in hormesis. Definition of hormesis; Observations confirmed in animal studies; Link between excessive caloric intake and cancer.