Tumor Resistance Explained by Hormesis

Calabrese, Edward J.; Nascarella, Marc A.
January 2010
Dose-Response;2010, Vol. 8 Issue 1, p80
Academic Journal
Enhanced drug (GDC 0449) resistance in a mouse model for human medulloblastoma is shown in the present paper to act via an hormetic response. This has significant implications, imposing constraints on the quantitative features of the dose response of the chemotherapeutic agent, affecting optimal study design, mechanism assessment strategy, potential for tumor rebound, patient relapse and disease outcome.


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