Hormesis is Applicable as a Pro-Healthy Aging Intervention in Mammals and Human Beings

Pardon, Marie-Christine
January 2010
Dose-Response;2010, Vol. 8 Issue 1, p22
Academic Journal
The aging of the population brings new heath challenges, and in particular, the need to implement suitable pro-healthy aging interventions. This paper discusses the potential of mild stressors inducing hormesis as a lifespan and healthspan extension strategy and how it can be applied to the human. There is some evidence that the anti-aging benefits of lifestyle factors, such as diet, exercise or engaging in activities may be achieved via hormetic regulation. This supports the validity of the concept in human. There are, however, gaps in knowledge and ethical barriers that need to be addressed to establish the suitability of the approach to the clinical context or the general geriatric population. In particular, we need to find out which stressors are safe for use as anti-aging interventions, when they have to be applied to achieve maximal benefits, how their therapeutic potential is altered by changes in the stress system induced by age and pathological conditions, and the extent to which the occurrence of adverse versus positive effects depends on interacting genetic and experiential factors.


Related Articles

  • Dietary restriction-induced life extension: a broadly based biological phenomenon. Masoro, Edward J. // Biogerontology;Jun2006, Vol. 7 Issue 3, p153 

    It is concluded that dietary restriction will extend the life of all species in the Animalia Kingdom, including the human species. This conclusion is based on the fact that hormesis is a component of the life-extending action and the other anti-aging effects of dietary restriction. It is also...

  • Aging Intervention, Prevention, and Therapy Through Hormesis. Rattan, Suresh I. S. // Journals of Gerontology Series A: Biological Sciences & Medical ;Jul2004, Vol. 59 Issue 7, p705 

    The phenomenon of hormesis is represented by mild stress-induced stimulation of maintenance and repair pathways resulting in beneficial effects for the cells and organisms. Anti-aging and life-prolonging effects of a wide variety of the so-called stressors, such as pro-oxidants, aldehydes,...

  • 1 Go for the burn. Lawton, Graham // New Scientist;6/3/2006, Vol. 190 Issue 2554, p36 

    The article reports that stressors such as poisons, radiation and heat can prove to be effective in reversing the ageing process. According to researchers, this counter-intuitive effect, called hormesis, has shown to extend longevity in yeast, fruit flies, protozoans, worms and rodents. If the...

  • Clues to a Long Life. DAHLBERG, KEN; ACKERMAN, FELICIA NIMUE; WOOL, LAURA; PRICE, THOMAS L.; YOUNG, JOANN M. // National Geographic;Sep2013, Vol. 224 Issue 3, p6 

    Letters to the editor are presented in response to an article which discussed attempts by scientists and researchers to increase the human longevity, including concerns about the decreased use of antibiotic drugs and many readers who do not wish to live to be 120 years old.

  • Can dietary restriction increase longevity in all species, particularly in human beings? Introduction to a debate among experts. Le Bourg, √Čric; Rattan, Suresh I. S. // Biogerontology;Jun2006, Vol. 7 Issue 3, p123 

    This article introduces a special issue of Biogerontology, for which a number of international experts who are still active or have been active in research on the effects of dietary restriction (DR) were asked to answer the following question. Do you think that DR can increase longevity in all...

  • BIOLOGICAL FACTORS AFFECTING AGEING AND LONGEVITY IN HUMANS. Bugeja, Vincent // Bold;Aug2012, Vol. 22 Issue 4, p2 

    The article explores the biological factors affecting aging and longevity in humans. It is stated that an increase in average life expectancy since 1881 is not due to an increase in potential lifespan but in ecological lifespan which includes mortality by diseases, accidents and starvation. The...

  • Longevity. Seland, Darryl // Appliance Design;Oct2014, Vol. 62 Issue 10, p4 

    The author comments on the concept of longevity or long life in people, manufactured goods and appliances. Topics discussed include the average life span of Americans as of 2011, Dan Buettner's article, "The Secrets of Long Life," which appeared in the November 2005 issue of "National...

  • Anti-Aging Industry Valued at $96.89 Billion. Archer, Shirley // IDEA Fitness Journal;Nov/Dec2008, Vol. 5 Issue 10, p78 

    The article reports that the increased interest in health, longevity and integrative approaches are stimulating the anti-aging business in the U.S. which is presently valued at $96.9 billion. The growth of the industry that includes products to enhance skin, hair and body appearance, as well as...

  • The Next Magic Cure-All? Chen, Ingfei // O, The Oprah Magazine;May2007, Vol. 8 Issue 5, p221 

    The article discusses the anti-aging effect of resveratrol. Resveratrol has been proven to lengthen life span in worms, fruit flies and fish. The substance is found in extract from red wine, grapes and peanuts. Longevity expert Steven Austad says that there is no guarantee that resveratrol will...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics