It is Time to Thoroughly Study the Effects of Mild Stress in Rodents, but also in Human Beings

Le Bourg, √Čric
January 2010
Dose-Response;2010, Vol. 8 Issue 1, p64
Academic Journal
Many experiments on the effect of mild stress on aging have been done in invertebrates, but not in mammals. Using mild stress to improve healthspan seems to be possible, because the few studies on humans which have been published appear to be promising. Particularly, one may wonder whether heat shocks could be of some use in therapy or as an integrated part of daily life of elderly people. However, the top priority is probably to study more thoroughly the effects of mild stress in rodents, and not only in invertebrates.


Related Articles

  • Supercentenarian.  // New Scientist;2/18/2006, Vol. 189 Issue 2539, p54 

    The article focuses on the longevity of life span of people. Living for a century is not much to boast about these days. Those who reach their 100th birthday are being eclipsed by an elite band of the extremely aged: the supercentenarians. research on supercentenarians in the U.S. shows that...

  • Longest-Living Mammals.  // Scholastic News -- Senior Edition;09/25/2000, Vol. 69 Issue 4, p3 

    Presents a graphical representation of the average life spans of long-living mammals.

  • Longest-Living Mammals.  // Scholastic News -- Edition 4;09/25/2000, Vol. 63 Issue 4, p3 

    Presents a graphical representation of the average life spans of long-living mammals.

  • Senescence Is More Important in the Natural Lives of Long- Than Short-Lived Mammals. Turbill, Christopher; Ruf, Thomas // PLoS ONE;2010, Vol. 5 Issue 8, p1 

    Background: Senescence has been widely detected among mammals, but its importance to fitness in wild populations remains controversial. According to evolutionary theories, senescence occurs at an age when selection is relatively weak, which in mammals can be predicted by adult survival rates....

  • Oxidation-Resistant Membrane Phospholipids Can Explain Longevity Differences Among the Longest-Living Rodents and Similarly-Sized Mice. Hulbert, A. J.; Faulks, Sally C.; Buffenstein, Rochelle // Journals of Gerontology Series A: Biological Sciences & Medical ;Oct2006, Vol. 61 Issue 10, p1009 

    Underlying causes of species differences in maximum life span (MLS) are unknown, although differential vulnerability of membrane phospholipids to peroxidation is implicated. Membrane composition and longevity correlate with body size; membranes of longer-living, larger mammals have less...

  • Neuroendocrine and Pharmacological Manipulations to Assess How Caloric Restriction Increases Life Span. Mobbs, Charles V.; Bray, George A.; Atkinson, Richard L.; Bartke, Andrzej; Finch, Caleb E.; Maratos-Flier, Eleftheria; Crawley, Jacqueline N.; Nelson, James F. // Journals of Gerontology Series A: Biological Sciences & Medical ;2001, Vol. 56 Issue suppl_1, p34 

    As part of an effort to review current understanding of the mechanisms by which caloric restriction (CR) extends maximum life span, the authors of the present review were requested to develop a list of key issues concerning the potential role of neuroendocrine systems in mediating these effects....

  • Can Rodent Longevity Studies be Both Short and Powerful? Robertson, Henry T.; Smith, Daniel L.; Pajewski, Nicholas M.; Weindruch, Richard H.; Garland, Theodore; Argyropoulos, George; Bokov, Alex; Allison, David B. // Journals of Gerontology Series A: Biological Sciences & Medical ;Mar2011, Vol. 66A Issue 3, p279 

    Many rodent experiments have assessed effects of diets, drugs, genes, and other factors on life span. A challenge with such experiments is their long duration, typically over 3.5 years given rodent life spans, thus requiring significant time costs until answers are obtained. We collected...

  • Use of Animal Models of Human Disease for Nonclinical Safety Assessment of Novel Pharmaceuticals. Morgan, Sherry J.; Elangbam, Chandikumar S.; Berens, Shawn; Janovitz, Evan; Vitsky, Allison; Zabka, Tanja; Conour, Laura // Toxicologic Pathology;Apr2013, Vol. 41 Issue 3, p508 

    Animal models of human disease are commonly utilized to gain insight into the potential efficacy and mode of action of novel pharmaceuticals. However, conventional (healthy) rodent and nonrodent models are generally utilized in nonclinical safety testing. Animal models of human disease may be...

  • SOCIO - ECONOMIC ASPECTS OF HEALTH AMONG ELDERLY IN INDIA. Chavan, M. R. // Golden Research Thoughts;Jul2013, Vol. 3 Issue 1, p1 

    The present century is often referred to as the age of 'Ageing'. Ageing is becoming a worldwide phenomenon with the growing world population. Ageing is a biological process experienced by mankind at all times. With increase in longevity or life span, there follows an increase in the proportion...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics