Stress to the Rescue: Is Hormesis a 'cure' for Aging?

Kahn, Arnold; Olsen, Anders
January 2010
Dose-Response;2010, Vol. 8 Issue 1, p48
Academic Journal
Despite the fact that the phenomenon of hormesis has been known for many years it is still very much an area of controversy just how useful hormetic treatments are in preventing age-related human diseases and increasing life expectancy. Since there are no data in humans demonstrating hormesis as an effective anti-ageing strategy we turn to a simple model organism for insight. In this review we explore what can be predicted about the usefulness of hormetic treatments in humans based upon studies conducted in the soil nematode Caenorhabditis elegans.


Related Articles

  • Multiple Stressors in Caenorhabditis elegans Induce Stress Hormesis and Extended Longevity. Cypser, James R.; Johnson, Thomas E. // Journals of Gerontology Series A: Biological Sciences & Medical ;Mar2002, Vol. 57A Issue 3, pB109 

    Focuses on a study which examined the hormetic and longevity effects induced by multiple stressors on the nematode Caenorhabditis elegans. Pretreatments and challenges conducted in the experiment; Details of heat-induced thermotolerance and life extension; Information on lack of hormetic...

  • Defining Development Through Gene Expression Profiling. Reinke, Valerie // Current Genomics;Apr2002, Vol. 3 Issue 2, p95 

    For an ever-increasing number of species, the completed genomic sequence is available, providing a means to identify all the genes encoded in a genome. The functional relationships between these genes must be defined in order to generate a cohesive understanding of the molecular events that...

  • Analysis of osm-6, a gene that affects sensory cilium structure and sensory neuron function in... Collet, Joan; Spike, Caroline A.; Lundquist, Erik A.; Shaw, Jocelyn E.; Herman, Robert K. // Genetics;Jan98, Vol. 148 Issue 1, p187 

    Investigates mutation in the Caenorhabditis elegans gene osm-6. Materials and methods used to conduct the study; Identification of molecular lesions associated with five osm-6 mutations; Localization of OSM-6; Results and discussion of the study.

  • Selective lineage specification by mab-19 during Caenorhabditis elegans male peripheral sense... Sutherlin, Marie E.; Emmons, Scott W. // Genetics;Nov94, Vol. 138 Issue 3, p675 

    Investigates the action of the gene mab-19 for specification of a subset of Caenorhabditis elegans male peripheral sense organ lineages. Isolation of mab-19 alleles for ray developmental mutations; Cell lineage alterations of male-specific divisions of the most posterior lateral hypodermal...

  • The first South African International Symposium on Developmental, Cell & Molecular Biology.  // South African Journal of Science;Nov/Dec96, Vol. 92 Issue 11/12, p569 

    Presents the abstract of the paper `Cleavage plane specification during the early development of Caenorhabditis elegans,' by John White, presented during the first South African International Symposium in Developmental, Cell and Molecular Biology held January 1996 in Johannesburg, South Africa.

  • Giving directions. Heinrichs, Arianne // Nature Reviews Molecular Cell Biology;Feb2006, Vol. 7 Issue 2, p78 

    The article discusses research being done on nucleoporins. It references a study by A. Schetter and colleagues, published in the December 2, 2005 issue of "Developmental Biology" which noted that after analyzing the nucleoporin NPP-1, there was a spindle-orientation defect in early...

  • The Caenorhabditis elegans Lifespan Machine. Stroustrup, Nicholas; Ulmschneider, Bryne E; Nash, Zachary M; López-Moyado, Isaac F; Apfeld, Javier; Fontana, Walter // Nature Methods;Jul2013, Vol. 10 Issue 7, p665 

    The measurement of lifespan pervades aging research. Because lifespan results from complex interactions between genetic, environmental and stochastic factors, it varies widely even among isogenic individuals. The actions of molecular mechanisms on lifespan are therefore visible only through...

  • SPD-3 Is Required for Spindle Alignment in Caenorhabditis elegans Embryos and Localizes to Mitochondria. Dinkelmann, Maria V.; Zhang, Haining; Skop, Ahna R.; White, John G. // Genetics;Nov2007, Vol. 177 Issue 3, p1609 

    During the development of multicellular organisms, cellular diversity is often achieved through asymmetric cell divisions that produce two daughter cells having different developmental potentials. Prior to an asymmetric cell division, cellular components segregate to opposite ends of the cell...

  • A C. elegans model of electronic cigarette use: Physiological effects of e-liquids in nematodes. Panitz, Daniel; Swamy, Harsha; Nehrke, Keith // BMC Pharmacology & Toxicology;12/4/2015, Vol. 16, p1 

    Background: Electronic cigarettes (e-cigs) have recently become very popular particularly among the younger generation. These nicotine delivery devices are viewed as a preferable alternative to more conventional forms of tobacco use and are thought to reduce the risk of chronic obstructive...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics