TITLE

Clinical Application of Ischemic Preconditioning in the Elderly

AUTHOR(S)
Abete, Pasquale; Cacciatore, Francesco; Testa, Gianluca; Della-Morte, David; Galizia, Gianluigi; Ferrara, Nicola; Rengo, Franco
PUB. DATE
January 2010
SOURCE
Dose-Response;2010, Vol. 8 Issue 1, p34
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A mild stress such as brief ischemic episodes may protect the heart from a successive and more prolonged myocardial ischemia (ischemic preconditioning). This phenomenon is considered a typical "hormetic mechanism" by which the heart is immunized from pathological insults such as myocardial ischemia. This mechanism is reduced with aging and it may be restored and/or preserved by drugs such as adenosine or nicorandil, a mitochondrial KATP channels, and lifestyle interventions such as physical activity and/or hypocaloric diet. Moreover, since the mechanisms involved in cardiac ischemic preconditioning have been established basic and clinical investigators are encouraged to test several drug in well-controlled animal and human studies in order to prevent and/or restore the age-related reduction of ischemic preconditioning.
ACCESSION #
59192557

 

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