Hormesis, Adaptive Epigenetic Reorganization, and Implications for Human Health and Longevity

Vaiserman, Alexander M.
January 2010
Dose-Response;2010, Vol. 8 Issue 1, p16
Academic Journal
Hormesis is a common phenomenon in a number of biomedical areas. However, the basic nature of this phenomenon remains largely unknown. Therefore, significant uncertainty is inevitable in attempts to apply hormesis as a pro-health and anti-aging tool. Evidence supporting that hormetic-like effects may be the result of a generalized wholeorganism adaptive epigenetic response is reviewed. Specific hormesis-inducing interventions during development would allow to achieve an optimal balance between activation and repression of various genes and thus to prevent age-related degenerative diseases and slow aging. The reasons that oscillating temperature mild stress could potentially be used for human application are discussed.


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