Hormesis, Adaptive Epigenetic Reorganization, and Implications for Human Health and Longevity
- Life Extension by Anti-Aging Drugs: Hormetic Explanation? Vaiserman, A. M. // American Journal of Pharmacology & Toxicology;2008, Vol. 3 Issue 1, p11
A number of chemicals including antioxidants, vitamins and hormones are widely advertised as anti-aging drugs (geroprotectors). It is usually believed that life-extending capacity of geroprotectors may be attributed to their specific anti-aging mechanisms, even without solid scientific evidence....
- "Stress" Protein Could Halt Aging Process, Say Scientists. Perry, R. Michael // Cryonics;3rd Quarter 2010, Vol. 31 Issue 3, p20
The article reports on the discovery by U.S. and British scientists of a protein that halts the degeneration of muscle mass caused by the body's aging process.
- Hormesis Against Aging and Diseases: Using Properties of Biological Adaptation for Health and Survival Improvement. Yashin, A. I. // Dose-Response;2010, Vol. 8 Issue 1, p41
The idea of using hormesis for postponing aging and improving human health has been recently discussed in scientific literature. This paper shows that redundancy in renewal capacity, some portion of which become activated and manifested in hormesis effects, may originate as a result of...
- Hormesis is Applicable as a Pro-Healthy Aging Intervention in Mammals and Human Beings. Pardon, Marie-Christine // Dose-Response;2010, Vol. 8 Issue 1, p22
The aging of the population brings new heath challenges, and in particular, the need to implement suitable pro-healthy aging interventions. This paper discusses the potential of mild stressors inducing hormesis as a lifespan and healthspan extension strategy and how it can be applied to the...
- Dietary restriction-induced life extension: a broadly based biological phenomenon. Masoro, Edward J. // Biogerontology;Jun2006, Vol. 7 Issue 3, p153
It is concluded that dietary restriction will extend the life of all species in the Animalia Kingdom, including the human species. This conclusion is based on the fact that hormesis is a component of the life-extending action and the other anti-aging effects of dietary restriction. It is also...
- Aging Intervention, Prevention, and Therapy Through Hormesis. Rattan, Suresh I. S. // Journals of Gerontology Series A: Biological Sciences & Medical ;Jul2004, Vol. 59 Issue 7, p705
The phenomenon of hormesis is represented by mild stress-induced stimulation of maintenance and repair pathways resulting in beneficial effects for the cells and organisms. Anti-aging and life-prolonging effects of a wide variety of the so-called stressors, such as pro-oxidants, aldehydes,...
- Gene expression: Uncovering sex-biased eQTLs. Muers, Mary // Nature Reviews Genetics;Nov2012, Vol. 13 Issue 11, p756
The article discusses research being done on expression quantitative trait loci (eQTLs) in female and male cell lines from HapMap populations which references the study "Sex-biased genetic effects on gene regulation in humans."
- Practical limitations of prescribing stress as an anti-aging treatment. Forbes, V.E. // Human & Experimental Toxicology;Jun2001, Vol. 20 Issue 6, p287
Comments on a study on the limitations of stress-induced hormesis for the prevention of aging. Complexity of the aging process; Difficulty in predicting the occurrence of hormesis; Variability among individuals that increases with age.
- (CONFERENCE) 'Epigenetics' Presents New Approach To Degenerative Disease. // Aging News Alert;4/30/2010, p10
The article reports that Epigenetics is the new approach for degenerative diseases in the U.S. The new field of Epigenetics discusses the external factors that can trigger gene expression for a particular disease, which can be passed along to offspring. It states that understanding the molecular...