Cumulative smoking exposure, duration of smoking cessation, and peripheral arterial disease in middle-aged and older Korean men

Young-Hoon Lee; Min-Ho Shin; Sun-Seog Kweon; Jin-Su Choi; Jung-Ae Rhee; Hye-Ran Ahn; Woo-Jun Yun; So-Yeon Ryu; Bok-Hee Kim; Hae-Sung Nam; Seul-Ki Jeong; Kyeong-Soo Park
January 2011
BMC Public Health;2011, Vol. 11 Issue 1, p94
Academic Journal
Background: We investigated the association of cumulative smoking exposure and duration of smoking cessation with peripheral arterial disease (PAD). Methods: The study population consisted of 2517 community-dwelling Korean men aged 50 years and older. Information on smoking characteristics such as smoking status, pack-years of smoking, and years since quitting smoking was collected using a standardized questionnaire. PAD was defined as an ankle-brachial index (ABI) less than 0.90 in either leg. Results: The odds ratio (OR, 95% confidence interval) of PAD was 2.31 (1.20-4.42) for former smokers and 4.30 (2.13-8.66) for current smokers, after adjusting for other cardiovascular risk factors. There was a significant doseresponse relationship between pack-years of smoking and PAD. Compared with those who had never smoked, the multivariate-adjusted ORs of PAD for smokers of 0.1-20.0, 20.1-40.0, and >40.0 pack-years were 2.15 (1.06-4.38), 2.24 (1.08-4.65), and 2.93 (1.41-6.09), respectively. There was a significant decrease in PAD risk as the years since quitting smoking increased. The multivariate-adjusted ORs of PAD for 11-20 and ≥21 years smoking cessation were 0.41 (0.19-0.86) and 0.49 (0.24-0.98), compared with current smokers. Conclusions: Cumulative smoking exposure and duration of smoking cessation were significantly associated with PAD in middle aged and older Korean men.


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