TITLE

Prevention of type 2 diabetes in a primary healthcare setting: Three-year results of lifestyle intervention in Japanese subjects with impaired glucose tolerance

AUTHOR(S)
Sakane, Naoki; Sato, Juichi; Tsushita, Kazuyo; Tsujii, Satoru; Kotani, Kazuhiko; Tsuzaki, Kokoro; Tominaga, Makoto; Kawazu, Shoji; Sato, Yuzo; Usui, Takeshi; Kamae, Isao; Yoshida, Toshihide; Kiyohara, Yutaka; Sato, Shigeaki; Kuzuya, Hideshi
PUB. DATE
January 2011
SOURCE
BMC Public Health;2011, Vol. 11 Issue 1, p40
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: A randomized control trial was performed to test whether a lifestyle intervention program, carried out in a primary healthcare setting using existing resources, can reduce the incidence of type 2 diabetes in Japanese with impaired glucose tolerance (IGT). The results of 3 years' intervention are summarized. Methods: Through health checkups in communities and workplaces, 304 middle-aged IGT subjects with a mean body mass index (BMI) of 24.5 kg/m² were recruited and randomized to the intervention group or control group. The lifestyle intervention was carried out for 3 years by public health nurses using the curriculum and educational materials provided by the study group. Results: After 1 year, the intervention had significantly improved body weight (-1.5 ± 0.7 vs. -0.7 ± 2.5 kg in the control; p = 0.023) and daily non-exercise leisure time energy expenditure (25 ± 113 vs. -3 ± 98 kcal; p = 0.045). Insulin sensitivity assessed by the Matsuda index was improved by the intervention during the 3 years. The 3-year cumulative incidence tended to be lower in the intervention group (14.8% vs.8.2%, log-rank test: p = 0.097). In a sub-analysis for the subjects with a BMI > 22.5 kg/m², a significant reduction in the cumulative incidence was found (p = 0.027). Conclusions: The present lifestyle intervention program using existing healthcare resources is beneficial in preventing diabetes in Japanese with IGT. This has important implications for primary healthcare-based diabetes prevention. Trial registration number: UMIN000003136.
ACCESSION #
59162567

 

Related Articles

  • Review: Lifestyle or pharmacologic interventions prevent or delay type 2 diabetes in impaired glucose tolerance: COMMENTARY. Bhagra, Sumit; Smith, Steven A. // ACP Journal Club;Jul/Aug2007, Vol. 147 Issue 1, p1 

    The authors reflect on a study, conducted by C.L. Gillies and colleagues, which focuses on the effectiveness of pharmacologic and lifestyle interventions in preventing type 2 diabetes mellitus (DM) in persons with impaired glucose tolerance. They view that sustained effects from preventive...

  • Primary Prevention of Type 2 Diabetes: Lifestyle Intervention Works and Saves Money, but What Should Be Done with Smokers? Tuomilehto, Jaakko // Annals of Internal Medicine;3/1/2005, Vol. 142 Issue 5, p381 

    This article focuses on the primary prevention of type 2 diabetes. A successful preventive intervention must, therefore, target several risk factors simultaneously. This characteristic of preventive interventions means that they are necessarily complex and require considerable resources....

  • Prevalence of co-morbid depression in out-patients with type 2 diabetes mellitus in Bangladesh. Roy, Tapash; Lloyd, Cathy E.; Parvin, Masuma; Mohiuddin, Khondker Galib B.; Rahman, Mosiur // BMC Psychiatry;2012, Vol. 12 Issue 1, p123 

    Background: Little is known about the prevalence of depression in people with diabetes in Bangladesh. This study examined the prevalence and factors associated with depression in out-patients with Type 2 diabetes in Bangladesh. Methods: In this cross-sectional study a random sample of 483...

  • CHROMIUM. Jain, Sushil K. // Diabetes Forecast;Jul2004, Vol. 57 Issue 7, p83 

    The rate of type 2 diabetes among children and adolescents is rising at such an alarming rate doctors and scientists are worsened about a public health crisis, in the coming years. Evidence is mounting that the lives of children who develop type 2 diabetes, could be cut short by deadly...

  • Consensus document on treatment of type 2 diabetes in patients with chronic kidney disease. Gómez-Huelgas, Ricardo; Martínez-Castelao, Alberto; Artola, Sara; Górriz, José L.; Menéndez, Edelmiro // Nefrologia;2014, Vol. 34 Issue 1, p34 

    Chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM) are highly prevalent chronic diseases that represent a significant public health problem and require multidisciplinary management. T2DM is the main cause of CKD in our setting and it is also a major comorbidity of non-diabetic...

  • Los pacientes diabéticos tipo 2 presentan peor evolución que los no diabéticos en diálisis peritoneal a expensas de su comorbilidad cardiovascular. Portolés, J.; Corchete, E.; López-Sánchez, P.; Coronel, F.; Ocaña, J.; Ortiz, A. // Nefrologia;Aug2009, Vol. 29 Issue 4, p336 

    Aim: To describe the characteristics, practice patterns, targets and outcome of the Type 2 diabetic patients (DM 2) in peritoneal dialysis (PD) and to compare them with non-diabetic ones. Methods: Prospective cohort study of every incident PD patient in a regional public health care system...

  • Latest Clinical Research: Low selenium levels linked to increased diabetes risk. Moberly, Tom // GP: General Practitioner;6/13/2012, p8 

    The article reports that according to a research, low levels of the trace element selenium are associated with an increased risk of developing type 2 diabetes. Selenium plays a vital part in an range of metabolic functions and in the body's defence against antioxidant damage. The researchers...

  • Age, body mass index and Type 2 diabetes—associations modified by ethnicity The DECODE-DECODA Study Group: Ethnicity and BMI in diabetes. The DECODE-DECODA Study Group // Diabetologia;Aug2003, Vol. 46 Issue 8, p1063 

    Aims/hypothesis. The aim of this study was to assess the effect of ethnicity on the association between age and body mass index as well as the prevalence of diabetes. Methods. We selected population-based studies carried out after 1980 in the DECODE/A studies representing different ethnic...

  • Cost-of-Illness Analysis of Type 2 Diabetes Mellitus in Iran. Javanbakht, Mehdi; Baradaran, Hamid R.; Mashayekhi, Atefeh; Haghdoost, Ali Akbar; Khamseh, Mohammad E.; Kharazmi, Erfan; Sadeghi, Aboozar // PLoS ONE;2011, Vol. 6 Issue 10, p1 

    Introduction Diabetes is a worldwide high prevalence chronic progressive disease that poses a significant challenge to healthcare systems. The aim of this study is to provide a detailed economic burden of diagnosed type 2 diabetes mellitus (T2DM) and its complications in Iran in 2009 year....

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics