Kolonizacja grzybami z rodzaju Malassezia a właściwości bariery skórno-naskórkowej w przebiegu łojotokowego zapalenia skóry

Boer, Magdalana; Maleszka, Romuald; Ratajczak-Stefańska, Violetta
December 2010
Medical Mycology / Mikologia;2010, Vol. 17 Issue 4, p211
Academic Journal
Background: Yeast-like fungi of the genus Malassezia are one of the most important factors of pathogenesis of seborrhoeic dermatitis (SD). The typical features of the damaged epidermo-dermal barrier integrity characterized these disease, might be associated with fungal colonization. Aim: The aim of the study was to assess the frequency of Malassezia fungi colonization in patients with SD in comparison to healthy volunteers. The values of skin surface pH value, sebum excretion, transepidermal water loss (TEWL) and stratum corneum hydration in patients with SD were compared with healthy population and the relationship between investigated microorganisms colonization and the changes in the measured skin biophysical parameters was assessed. Material and methods: 43 patients with SD and 44 healthy volunteers were included into the study. Malassezia fungi were isolated from the T-zone of the face. Species identification was performed using its morphological features and physicochemical proprieties. The instrumental measurement of skin surface pH, sebum excretion, TEWL and hydration were performed using Skin-pH-MeterR PH 905, SebumeterR SM 815, TewameterR TM 300 and CorneometerR CM 825. Results: The study demonstrated significant higher face skin colonization rates of Malassezia fungi in the group of patients with SD in comparison to the controls. The predominant two fungi species were M. globosa and M. sympodialis in both analyzed groups. The considerably higher sebum excretion and TEWL values and the statistically lower stratum corneum hydration were observed in SD in comparison to healthy volunteers. Conclusion: Demonstrated differences of the biophysical skin properties values, between patients with SD in comparison to healthy population, might be associated with the significantly higher isolation frequency of Malassezia fungi in course of these disease. On the other hand, lack of direct relationship between fungal colonization and the values of the measured skin parameters confirms multifactorial etiology of these disease.


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