Overexpression of truncated IκBα potentiates TNF-α-induced apoptosis in mesangial cells

Hirahashi, Junichi; Takayanagi, Atsushi; Hishikawa, Keiichi; Takase, Osamu; Chikaraishi, Akihiro; Hayashi, Matsuhiko; Shimizu, Nobuyoshi; Saruta, Takao
March 2000
Kidney International;Mar2000, Vol. 57 Issue 3, p959
Academic Journal
Investigates the effects of the specific inhibition of the nuclear factor-kappa B (NF-kB) on tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis in rat mesangial cells (MCs). Construction of recombinant adenovirus vector; Detection of DNA fragmentation; Inducement of apoptosis in MCs under inflammatory conditions.


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