TITLE

BinaxNOW -- An immunochromatographic test for the diagnosis of human influenza viruses: Comparison with viral culture and polymerase chain reaction

AUTHOR(S)
Bhattacharya, S.; Osman, H.
PUB. DATE
January 2011
SOURCE
Indian Journal of Medical Microbiology;Jan2011, Vol. 29 Issue 1, p19
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: A rapid test for influenza viruses (Binax NOW®) was evaluated. Materials and Methods: In season-1, 35 respiratory samples were tested retrospectively; in season-2, 45 samples were tested prospectively [gold-standard: viral culture in season-1, culture+ reverse transcriptase-polymerase chain reaction (RT-PCR) in season-2]. Results: Sensitivity for Binax for influenza A was 59.3 and 0% in season-1 and -2, respectively. Sensitivity was low for influenza B (33.3% in season-1, 26.1% in season-2). Samples having low viral load were more likely to have a negative Binax test. Specificity of Binax was high (100 and 94.7% with influenza A and B, respectively). Conclusion: Sensitivity information provided in the kit insert does not always reflect post licensure performance in clinical settings.
ACCESSION #
58658769

 

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