Isovoxel-Based Morphology of Hippocampi and Amygdalae: a Comparison of Manual and Automated Volume Measurements

Bertoni, M. A.; Sclavi, N. E.
December 2010
Neuroradiology Journal;Dec2010, Vol. 23 Issue 6, p711
Academic Journal
This study evaluated the correlation between manual and automated morphometric measurements of hippocampi and amygdalae. Twenty-three patients with no history of seizures and normal electroencephalograms were examined with a standardized MRI protocol that included isovoxel volumetric acquisitions of the brain. Images were evaluated in axial-oblique plane to trace manually the grey matter contours of hippocampi and amygdalae obtaining their volumes. They were also processed automatically carrying out segmentation and sub segmentation aligning images (AC-PC) and standardizing them into Talairach space to obtain then comparable grey matter volumes. Tabled results were age, gender and volumes of each side from both, manual and automated measurements. Forward stepwise multiple regression analyses were carried out considering sex and age as independent and hippocampi-amygdalae as dependent variables. Linear regression analyses were then carried out considering for the total of cerebral hemispheres each manual measurement as independent and automatically obtained volumes as dependent variables. In the multiple regression analyses the following values were obtained: age-gender vs. manual measurements showed r=0.83; r2=0.69; adjustedr2=0.64 F(3,19)=14.36 while age-gender vs. automated values showed r=0.86; r2=-0. 74; adjustedr2=0.70; F(3,19)=18.81. Linear regression between manual and automated measurements for all hemispheres showed for hippocampus: r=-0.97; r2=0.95; F(1,44)896.59. For amygdala results were: r=0.94; r2=0.89; F(1,44)=391.11. The results of these analyses suggest that both manual and automated procedures of measurement are highly consistent. A regression between age and volumes of both hippocampus and amygdala was also noted.


Related Articles

  • Is radiological evaluation as good as computer-based volumetry to assess hippocampal atrophy in Alzheimer's disease? Boutet, Claire; Chupin, Marie; Colliot, Olivier; Sarazin, Marie; Mutlu, Gurkan; Drier, Aurélie; Pellot, Audrey; Dormont, Didier; Lehéricy, Stéphane // Neuroradiology;Dec2012, Vol. 54 Issue 12, p1321 

    Introduction: Hippocampus volumetry is a useful surrogate marker for the diagnosis of Alzheimer's disease (AD). Our purpose was to compare visual assessment of medial temporal lobe atrophy made by radiologists with automatic hippocampal volume and to compare their performances for the...

  • Gray matter concentration and effective connectivity changes in Alzheimer's disease: a longitudinal structural MRI study. Li, Xingfeng; Coyle, Damien; Maguire, Liam; Watson, David; McGinnity, Thomas // Neuroradiology;Oct2011, Vol. 53 Issue 10, p733 

    Introduction: Understanding disease progression in Alzheimer's disease (AD) awaits the resolution of three fundamental questions: first, can we identify the location of 'seed' regions where neuropathology is first present? Some studies have suggested the medial temporal lobe while others have...

  • Using MRI for Assessing Velopharyngeal Structures and Function. Perry, Jamie L.; Sutton, Bradley P.; Kuehn, David P.; Gamage, Jinadasa K. // Cleft Palate-Craniofacial Journal;Jul2014, Vol. 51 Issue 4, p476 

    Objective: Direct visualization of the velopharynx and, in particular, the levator muscle is particularly important in the assessment of velopharyngeal function and normal speech production. The purpose of this study is to demonstrate the development of a static and dynamic magnetic resonance...

  • The Smoothing Artifact of Spatially Constrained Canonical Correlation Analysis in Functional MRI. Cordes, Dietmar; Mingwu Jin; Curran, Tim; Nandy, Rajesh // International Journal of Biomedical Imaging;2012, p1 

    A wide range of studies show the capacity of multivariate statistical methods for fMRI to improve mapping of brain activations in a noisy environment. An advanced method uses local canonical correlation analysis (CCA) to encompass a group of neighboring voxels instead of looking at the single...

  • Pilocytic Astrocytomas in Elderly Adults. Kitamura, N.; Hasebe, T.; Kasai, R.; Kasuya, S.; Nakatsuka, T.; Kudo, H.; Higuchi, M.; Nakano, K.; Hiruta, N.; Kameda, N.; Ogata, K.; Watanabe, Y.; Morita, H.; Terada, H. // Neuroradiology Journal;Dec2010, Vol. 23 Issue 6, p690 

    Pilocytic astrocytomas are classified as WHO grade I gliomas that occur predominantly in children and young adults. Reports of the tumors in elderly adults are extremely rare. We describe two cases of pilocytic astrocytoma in elderly adults, a 68-year-old man and a 71-year-old woman. Brain...

  • Global diffusion tensor imaging derived metrics differentiate glioblastoma multiforme vs. normal brains by using discriminant analysis: introduction of a novel whole-brain approach. Roldan-Valadez, Ernesto; Rios, Camilo; Cortez-Conradis, David; Favila, Rafael; Moreno-Jimenez, Sergio // Radiology & Oncology;2014, Vol. 48 Issue 2, p127 

    Background. Histological behavior of glioblastoma multiforme suggests it would benefit more from a global rather than regional evaluation. A global (whole-brain) calculation of diffusion tensor imaging (DTI) derived tensor metrics offers a valid method to detect the integrity of white matter...

  • Neurotoxicity of low-dose repeatedly intranasal instillation of nano- and submicron-sized ferric oxide particles in mice. Bing Wang; Weiyue Feng; Yiqun Gu; Hong Ouyang; Yuliang Zhao; Zhifang Chai; Haifang Wang // Journal of Nanoparticle Research;Jan2009, Vol. 11 Issue 1, p41 

    Abstract  Olfactory tract has been demonstrated to be an important portal for inhaled solid nanoparticle transportation into the central nervous system (CNS). We have previously demonstrated that intranasally instilled Fe2O3 nanoparticles could transport into the CNS via olfactory pathway....

  • Teen Anger and Aggression . . . Neurotransmitter Deficiency. Sahley, Billie J. // MMRC Health Educator Reports;2004, p1 

    The article focuses on limbic system, located deep in the brain's interior is associated with the roots of anxiety, panic and fear. The limbic system stays in overdrive due to an excessive production of sex hormones. The limbic system connects key parts of the brain such as the amygdala,...

  • Limbic System.  // Encyclopedic Reference of Molecular Pharmacology;2004, p556 

    An encyclopedia entry for the term "limbic system" is presented. It is part of the brain that comprises of the amygdala, hippocampus and evolutionarily old regions of the cortex. It plays a part in the representation of emotions in the brain.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics