TITLE

POLYMORPHISM OF NATURAL-RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 1 (NRAMP1) D543N GENE AND EXPRESSION OF NRAMP1 ON LUNG TUBERCULOSIS PATIENTS AND NURSES IN SURABAYA

AUTHOR(S)
Anggraini, Rahayu; Nugraha, Jusak; Sudiana, I. Ketut; Mertaniasih, Ni Made; Putra, Suhartono Taat; Suryohudoyo, Purnomo
PUB. DATE
April 2010
SOURCE
Folia Medica Indonesiana;abr2010, Vol. 46 Issue 2, p78
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Tuberculosis caused by Mycobacterium tuberculosis which can cause death, where the situation is more compounded when the cause is caused by genetic factors. The purpose of this study will evaluate the role of gene polymorphisms D543N natural-resistance-associated macrophage protein 1 (NRAMP1) and the expression of NRAMP1 in nurse and patient with pulmonary tuberculosis. NRAMP1 gene polymorphism D543N occur because there are nucleotide changes at codon 543 in exon 15, which displacement causes a change to aspartic acid asparagin. NRAMP1 gene is expressed not only in macrophages also on the blood cells known as peripheral blood mononuclear cells (PBMC). NRAMP1 gene encoding a protein, transport protein NRAMP1 is a bivalent metal ion that serves as a channel for divalent ions including Fe++ ions. Fe++ ions can inhibit the growth of M. tuberculosis and will eventually kill M. tuberculosis (Blackwell, 2001). If because there is a mutation in the NRAMP1 gene produces proteins that are not functional or NRAMP1 mutations cause NRAMP1 protein expression decreased, so that the growth inhibition of M. tuberculosis will be lost or reduced, causing the germs will breed freely in pulmonary alveolar macrophages. Results variant genotype A/A polymorphism D543N occurred only in patients with pulmonary tuberculosis. Average yield of protein expression of NRAMP1 in nurses is higher than pulmonary tuberculosis patients. In conclusion, the polymorphism D543N A allele tended to cause an average of NRAMP1 expression decreased, so that the variant genotype A/A gene NRAMP1 D543N polymorphism is gene causes susceptibility to infection of M. tuberculosis.
ACCESSION #
58601607

 

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