Adrian, Silvanus; Yoewarini, Endang
October 2009
Folia Medica Indonesiana;oct2009, Vol. 45 Issue 4, p269
Academic Journal
To investigate the correlation between Cyclin D1 expression and the clinical staging, tumor cell grading and the lymph node metastasis of non kereatinizing squamous cell cervical cancer. The research design s observational study with cross sectional approach in Gynecologi Oncology Clinic and Pathology Anatomy Department of Dr Soetomo General Hospital, Surabaya. The samples are tissues (cervix and lymph node) covered with paraffin block collected from radical hysterectomies in Dr. Soetomo General Hospital, Surabaya Janurai 1st, 2003 to November 31st, 2006. 10 samples were collected consecutively for each clinical staging (IA, IB, IIA), thus 30 samples totally. All samples were processed by immunohistochemestry using monoklonal mouse anti-human cyclin D1, Glostrup Denmark and cyclin D1 expression were evaluated blindly, regardless of clinical staging, tumor cell grading and lymph node metastasis. Cyclin D1 expression were counted semiquantitavely with negative and positive controls. The correlation of cyclin D1, linical staging and tumor cell grading was analysed by Spearman's Rho. The correlation fo cyclin D1 expression and lymph node metastasis was analysed by logistic regreesion. There were significans difference in cyclin D1 expression with grading cell tumor (p : 0,000), clinical staging (p : 0,05) and lymph node metastasis (p : 0.03). In non keratinizing squamous cell cervical carcinoma, the higher cyclin D1 expression, the higher the tumor cell grading (r : 0,939) , the higher the clinical staging (r : 0.005). The higher cyclin D1 expression was assosiated with positive lymph node metastasis (r : 0,754).


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