TITLE

Identification of a Novel Fibronectin-Aggrecan Complex in the Synovial Fluid of Knees with Painful Meniscal Injury

AUTHOR(S)
Scuderi, Gaetano J.; Golish, S. Raymond; Cook, Frank F.; Cuellar, Jason M.; Bowser, Robert P.; Hanna, Lewis S.
PUB. DATE
February 2011
SOURCE
Journal of Bone & Joint Surgery, American Volume;2/16/2011, Vol. 93-A Issue 4, p336
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Molecular biomarkers associated with knee pain may be useful as diagnostic modalities, prognostic indicators, and surrogate end points for therapeutic trials. The present study describes a novel complex of fibronectin and aggrecan that is present in the affected knee of patients with pain and meniscal abnormality. Methods: The present prospective study included thirty patients with knee pain, mechanical symptoms, and magnetic resonance imaging findings that were positive for a meniscal tear who chose arthroscopic partial meniscectomy after unsuccessful nonoperative management. Synovial fluid was aspirated at the time of surgery and was assayed for the fibronectin-aggrecan complex with use of a heterogeneous enzyme-linked immunosorbent assay (ELISA). The results were compared with knee aspirates from ten asymptomatic volunteers with no pain who underwent magnetic resonance imaging of the knee. Results: The mean optical density (and standard deviation) of the fibronectin-aggrecan complex was significantly greater in synovial fluid from knees undergoing arthroscopic surgery as compared with fluid from asymptomatic controls (13.29 ± 8.48 compared with 0.03 ± 0.09; p < 0.001). The mean age in the study group was significantly greater than in control group (46.0 ± 12.6 compared with 38.5 ± 6.0 years; p = 0.02), but controlling for age did not affect the results. Post hoc, an optical density cutoff value of 0.3 distinguished the study group from the control group with 100% accuracy. Conclusions: A novel fibronectin-aggrecan complex is present in the synovial fluid of painful knees with meniscal abnormality. The fibronectin-aggrecan complex may prove to be useful as a clinical biomarker or therapeutic target. Further research is warranted to correlate functional outcome after surgery with the fibronectin-aggrecan complex and other cartilage biomarkers.
ACCESSION #
58475338

 

Related Articles

  • Arthroscopic synovial biopsy in definitive diagnosis of joint diseases: An evaluation of efficacy and precision. Singhal, Onis; Kaur, Viplesh; Kalhan, Shivani; Singhal, Manish Kumar; Gupta, Anshu; Machave, Y. V. // International Journal of Applied & Basic Medical Research;Jul-Dec2012, Vol. 2 Issue 2, p102 

    Context: Arthritis is an important cause of morbidity, presenting as monoarticular or polyarticular lesion. Arthroscopic synovial aspiration and biopsy can help in arriving specific etiological diagnosis. Aim and Objectives: To evaluate the efficacy of arthroscopic synovial biopsy as a...

  • Simple Visual Parameters for Objective Assessment of Arthroscopic Skill. Alvand, A.; Khan, T.; Al-Ali, S.; Jackson, W. R.; Price, A. J.; Rees, J. L. // Journal of Bone & Joint Surgery, American Volume;7/3/2012, Vol. 94-A Issue 13, p1247 

    Background: Restrictions placed on the working hours of doctors over the past decade have resulted in substantial changes to the training and assessment of orthopaedic surgical residents. Many who are responsible for training the surgeons of the future have become concerned that this reduced...

  • Changes in synovial fluid biochemical markers following arthroscopic surgery in patients with knee osteoarthritis. Nakajima, Arata; Nakagawa, Koichi; Aoki, Yasuchika; Sonobe, Masato; Shibata, Yoshifumi; Yamazaki, Masashi; Murakami, Masazumi // Rheumatology International;Jan2013, Vol. 33 Issue 1, p209 

    Although arthroscopic surgery (AS) for knee osteoarthritis has been widely employed, scientific evidence is lacking. The purpose of this study was to investigate temporal changes in synovial fluid levels of biochemical markers associated with cartilage metabolism following AS. Twenty-five knees...

  • The "Hoover" (vacuum cleaner) technique for calcifying tendonitis deposits excision and removal of the calcific debris. Ehud, Atoun; Ehud, Rath; Alexander, Van Tongel; Ali, Narvani; Giusseppe, Sforza; Ofer, Levy // International Journal of Shoulder Surgery;Jul-Sep2012, Vol. 6 Issue 3, p97 

    A new technical tip for the improvement of the arthroscopic treatment of symptomatic calcifying tendinitis is described. Arthroscopic excision of calcifying tendonitis may result with multiple minute calcific debris in the subacromial bursa, causing severe post operative pain due to chemical...

  • Comparison between open and arthroscopic procedures for lateral clavicle resection. Duindam, Nick; Kuiper, Jesse; Hoozemans, Marco; Burger, Bart // International Orthopaedics;Apr2014, Vol. 38 Issue 4, p783 

    Purpose: Arthroscopic lateral clavicle resection (LCR) is increasingly used, compared to an open approach, but literature does not clearly indicate which approach is preferable. The goal of this study was to compare function and pain between patients who underwent lateral clavicle resection...

  • Arthroscopic surgery for degenerative tears of the meniscus: a systematic review and meta-analysis. Khan, Moin; Evaniew, Nathan; Bedi, Asheesh; Ayeni, Olufemi R.; Bhandari, Mohit // CMAJ: Canadian Medical Association Journal;10/7/2014, Vol. 186 Issue 14, p1057 

    Background: Arthroscopic surgery for degenerative meniscal tears is a commonly performed procedure, yet the role of conservative treatment for these patients is unclear. This systematic review and meta-analysis evaluates the efficacy of arthroscopic meniscal débridement in patients with knee...

  • Omeros What They 'Knee'-ded: Mixed Phase III, New Trial Due. Osborne, Randy // BioWorld Today;1/ 2/2013, Vol. 24 Issue 1, p1 

    The article reports on the results of Omeros Corp.'s Phase III trial with OMS103HP in knee surgery which gave the company a roadmap for a study on postoperative pain. Gregory Demopulos, Omeros' president, says that the use of the Visual Analog Scale (VAS) for pain is an endpoint with which the...

  • Should you be scoped?  // Prevention;Aug97, Vol. 49 Issue 8, p82 

    Discusses arthroscopic surgery. The benefits; The difficulty with rehabilitation afterward; Advice if you are considering the procedure.

  • Pointers on knee surgery. Young, Stephanie; Kusek, Kristyn // Glamour;July97, Vol. 95 Issue 7, p33 

    Offers advice on how to prepare for arthroscopic knee surgery, a common orthopedic procedure to treat persistent knee pain, locking or instability due to a torn cartilage, for example. How the procedure is carried out; What to do before and after surgery.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics