Blood Storage Duration and Biochemical Recurrence of Cancer After Radical Prostatectomy

Cata, Juan P.; Klein, Eric A.; Hoeltge, Gerald A.; Dalton, Jarrod E.; Mascha, Edward; O'Hara, Jerome; Russell, Amanda; Kurz, Andrea; Ben-Elihayhu, Shamgar; Sessler, Daniel I.
February 2011
Mayo Clinic Proceedings;Feb2011, Vol. 86 Issue 2, p120
Academic Journal
OBJECTIVE: To test the hypothesis that perioperative transfusion of allogeneic and autologous red blood cells (RBCs) stored for a prolonged period speeds biochemical recurrence of prostate cancer after prostatectomy. PATIENTS AND METHODS: We evaluated biochemical prostate cancer recurrence in men who had undergone radical prostatectomy and perioperative blood transfusions from July 6, 1998, through December 27, 2007. Those who received allogeneic blood transfusions were assigned to nonoverlapping "younger," "middle," and "older" RBC storage duration groups. Those who received autologous RBC transfusions were analyzed using the maximum storage duration as the primary exposure. We evaluated the association between RBC storage duration and biochemical recurrence using multivariable Cox proportional hazards regression. RESULTS: A total of 405 patients received allogeneic transfusions. At 5 years, the biochemical recurrence-free survival rate was 74%, 71%, and 76% for patients who received younger, middle, and older RBCs, respectively; our Cox model indicated no significant differences in biochemical recurrence rates between the groups (P=.82; Wald test). Among patients who received autologous transfusions (n=350), maximum RBC age was not significantly associated with biochemical cancer recurrence (P=.95). At 5 years, the biochemical recurrence-free survival rate was 85% and 81% for patients who received younger and older than 21-day- old RBCs, respectively. CONCLUSION: In patients undergoing radical prostatectomy who require RBC transfusion, recurrence risk does not appear to be independently associated with blood storage duration.


Related Articles

  • Contemporary Radical Prostatectomy. Qiang Fu; Moul, Judd W.; Sun, Leon // Prostate Cancer (20903111);2011, p1 

    Purpose. Patients diagnosed with clinically localized prostate cancer have more surgical treatment options than in the past. This paper focuses on the procedures' oncological or functional outcomes and perioperative morbidities of radical retropubic prostatectomy, radical perineal prostatectomy,...

  • Body mass index is not a predictor of biochemical recurrence after radical prostatectomy in Dutch men diagnosed with prostate cancer. Kok, Dieuwertje; Roermund, Joep; Aben, Katja; Luijtgaarden, Moniek; Karthaus, Herbert; Vierssen Trip, Oncko; Kampman, Ellen; Alfred Witjes, J.; Kiemeney, Lambertus // World Journal of Urology;Oct2011, Vol. 29 Issue 5, p695 

    Purpose: To determine the effect of body mass index (BMI) on clinical and pathological characteristics at time of diagnosis and on risk of biochemical recurrence after radical prostatectomy among Dutch men diagnosed with prostate cancer. Methods: In total, 1,116 prostate cancer patients with...

  • Parameters derived from the postoperative decline in ultrasensitive PSA improve the prediction of radical prostatectomy outcome. Vesely, Stepan; Jarolim, Ladislav; Schmidt, Marek; Minarik, Ivo; Dusek, Pavel; Babjuk, Marko // World Journal of Urology;Apr2013, Vol. 31 Issue 2, p299 

    Purpose: Contemporary tools estimating increased risk of prostate cancer (PCa) relapse after radical prostatectomy (RP) are far from perfect and there has been an intensive search for additional predictive variables. We aimed to explore whether the parameters of postoperative ultrasensitive...

  • XPA-210: a new proliferation marker determines locally advanced prostate cancer and is a predictor of biochemical recurrence. Aufderklamm, Stefan; Hennenlotter, Jörg; Todenhoefer, Tilman; Gakis, Georgios; Schilling, David; Vogel, Ulrich; Kuehs, Ursula; Dlugosch, Johannes; Knapp, Judith; Merseburger, Axel; Gerber, Valentina; Ordelheide, Anna; Hevler, Joachim; Stenzl, Arnulf; Schwentner, Christian // World Journal of Urology;Aug2012, Vol. 30 Issue 4, p547 

    Purpose: XPA-210 is a proliferation marker derived from Thymidine kinase-1. It is of clinical significance in kidney, breast, and bladder cancer. There are no data available for XPA-210 in prostate cancer (PC). Herein, we aim to determine the clinical usefulness of XPA-210 in PC. Materials and...

  • Higher Prostate Weight Is Inversely Associated with Gleason Score Upgrading in Radical Prostatectomy Specimens. Reis, Leonardo Oliveira; Zani, Emerson Luis; Freitas, Leandro L. L.; Denardi, Fernandes; Billis, Athanase // Advances in Urology;2013, p1 

    Background. Protective factors against Gleason upgrading and its impact on outcomes after surgery warrant better definition. Patients andMethods. Consecutive 343 patients were categorized at biopsy (BGS) and prostatectomy (PGS) as Gleason score, =6, 7, and =8; 94 patients (27.4%) had PSA...

  • Neoadjuvant hormonal therapy is a feasible option in laparoscopic radical prostatectomy. Taku Naiki; Noriyasu Kawai; Takehiko Okamura; Daisuke Nagata; Yoshiyuki Kojima; Hidetoshi Akita; Takahiro Yasui; Keiichi Tozawa; Kenjiro Kohri // BMC Urology;2012, Vol. 12 Issue 1, p36 

    Background: Few reports can be found in the literature with respect to the impact of neoadjuvant hormonal therapy (NHT) on operative parameters on laparoscopic radical prostatectomy (LRP) in a large study. The aim of this study was to evaluate the safety and efficacy of NHT prior to LRP for...

  • Secondary Cancer and Relapse Rates Following Radical Prostatectomy for Prostate-Confined Cancer. Wesley, David; Cox, Hugh F. // Journal of Insurance Medicine;2007, Vol. 39 Issue 4, p242 

    In the SEER database, it is relatively easy to identify secondary cancers that follow an initial diagnosis of cancer. However, the SEER public-use data does not explicitly capture relapse of the initial cancer. One can assume that organ-confined prostate cancer treated by radical prostatectomy...

  • The log-beta Weibull regression model with application to predict recurrence of prostate cancer. Ortega, Edwin; Cordeiro, Gauss; Kattan, Michael // Statistical Papers;Feb2013, Vol. 54 Issue 1, p113 

    We study the properties of the called log-beta Weibull distribution defined by the logarithm of the beta Weibull random variable (Famoye et al. in J Stat Theory Appl 4:121-136, ; Lee et al. in J Mod Appl Stat Methods 6:173-186, ). An advantage of the new distribution is that it includes as...

  • Less invasive prostate surgery may have drawbacks.  // American Journal of Hematology/Oncology;Nov2009, Vol. 8 Issue 11, p526 

    The article reports on the findings of the study on the potential of patients who have minimally invasive radical prostatectomy (MIRP) to have lower rates of blood transfusions, breathing problems, and internal scarring. Investigators of the study made a review of data from patients who...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics