Protein-Protein Interfaces

February 2011
Science Teacher;Feb2011, Vol. 78 Issue 2, p21
Academic Journal
The article discusses a research study conducted by Georgia Institute of Technology Center for the Study of Systems Biology director Jeffrey Skolnick and colleague Mu Gao in 2011 on the 1,000 protein-protein interfaces whose structures depend on protein physics. The phenomena of the interfaces reportedly has an implication for drug development projects. The researchers observed that physical characteristics of the protein enable them to interact in the molecular structure.


Related Articles

  • Study Classifies and Uses Artificial Proteins to Analyze Protein-Protein Interfaces.  // Trends in Molecular Sciences;2011, Vol. 3 Issue 1, p73 

    The article reports on a study which suggests that there may be roughly a thousand structurally-distinct protein-protein interfaces, and their structures depend largely on the simple physics of the proteins. Jeffrey Skolnick, director of the Center for the Study of Systems Biology at the Georgia...

  • Cracking Cellular Motion. Clabby, Catherine // American Scientist;Jan/Feb2011, Vol. 99 Issue 1, p28 

    The article deals with a study by Jeffrey Skolnick and Tadashi Ando of Georgia Institute of Technology about the movements of molecules inside cells. The researchers found that diffusion affects movement inside cells and that when a molecule moves, the cellular fluid surrounding it is disturbed....

  • Bioinformatics' New Frontier.  // PharmaGenomics;Jul/Aug2003, Vol. 3 Issue 6, p10 

    Focuses on the first annual Frontiers in Bioinformatics symposium organized by the University of New York at Buffalo Center of Excellence in Bioinformatics in June 2003. Programs featured in the symposium; Opportunity provided by the event on bioinformatics technology information and...

  • Homodimeric Enzymes as Drug Targets. Cardinale, D.; Salo-Ahen, O. M. H.; Ferrari, S.; Ponterini, G.; Cruciani, G.; Carosati, E.; Tochowicz, A. M.; Mangani, S.; Wade, R. C.; Costi, M. P. // Current Medicinal Chemistry;Mar2010, Vol. 17 Issue 9, Special section p1 

    Many enzymes and proteins are regulated by their quaternary structure and/or by their association in homoand/ or hetero-oligomer complexes. Thus, these protein-protein interactions can be good targets for blocking or modulating protein function therapeutically. The large number of oligomeric...

  • In Silico and In Vitro: Identifying New Drugs. Pauli, Ivani; Timmers, Luis Fernando Saraiva Macedo; Caceres, Rafael Andrade; Soares, Milena Botelho Pereira; de Azevedo Jr., Walter Filgueira // Current Drug Targets;Dec2008, Vol. 9 Issue 12, p1054 

    Drug development is a high cost and laborious process, requiring a number of tests until a drug is made available in the market. Therefore, the use of methods to screen large number of molecules with less cost is crucial for faster identification of hits and leads. One strategy to identify...

  • PriaXplore® - a novel technology platform for the identification of small molecule modulators of protein-protein interactions. Eyrisch, Susanne; Girschick, Tobias; Ross, Günter; Kalinski, Cédric; Khazak, Vladimir; Weber, Lutz // Journal of Cheminformatics;2013, Vol. 5 Issue S1, p1 

    A conference paper about the development of PriaXplore®, a novel technology platform for the identification of small molecule modulators of protein-protein interactions (PPIs) is presented. It informs that the protein-protein interactions are broadly recognized as an emerging target class for...

  • Progress and challenges in predicting protein interfaces. Esmaielbeiki, Reyhaneh; Krawczyk, Konrad; Knapp, Bernhard; Nebel, Jean-Christophe; Deane, Charlotte M. // Briefings in Bioinformatics;Jan2016, Vol. 17 Issue 1, p117 

    Themajority of biological processes aremediated via protein-protein interactions. Determination of residues participating in such interactions improves our understanding ofmolecularmechanisms and facilitates the development of therapeutics. Experimental approaches to identifying interacting...

  • Potential for Protein Surface Shape Analysis Using Spherical Harmonics and 3D Zernike Descriptors. Lee Sael // Cell Biochemistry & Biophysics;Jul2009, Vol. 54 Issue 1-3, p23 

    Abstract  With structure databases expanding at a rapid rate, the task at hand is to provide reliable clues to their molecular function and to be able to do so on a large scale. This, however, requires suitable encodings of the molecular structure which are amenable to fast...

  • PConPy--a Python module for generating 2D protein maps. Hui Kian Ho; Michael J. Kuiper; Ramamohanarao Kotagiri // Bioinformatics;Dec2008, Vol. 24 Issue 24, p2934 

    Summary: PConPy is an open-source Python module for generating protein contact maps, distance maps and hydrogen bond plots. These maps can be generated in a number of publication-quality vector and raster image formats. Contact maps can be annotated with secondary structure and hydrogen bond...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics