Prevalence of the metabolic syndrome in Luxembourg according to the Joint Interim Statement definition estimated from the ORISCAV-LUX study

Alkerwi, Ala'a; Donneau, Anne-Françoise; Sauvageot, Nicolas; Lair, Marie-Lise; Scheen, André; Albert, Adelin; Guillaume, Michèle
January 2011
BMC Public Health;2011, Vol. 11 Issue 1, p1
Academic Journal
Background: The prevalence of the metabolic syndrome (MS) has been determined in many countries worldwide but never in Luxembourg. This research aimed to 1) establish the gender- and age-specific prevalence of MS and its components in the general adult population of Luxembourg, according to the most recent Joint Interim Statement (JIS) definition, by using both the high and low cut-off points to define abdominal obesity, and 2) compare and assess the degree of agreement with the Revised National Cholesterol Education Programme-Adult Treatment Panel III (R-ATPIII) and the International Diabetes Federation (IDF) definitions. Methods: A representative stratified random sample of 1349 European subjects, aged 18-69 years, participated to ORISCAV-LUX survey. Logistic regression and odds ratios (OR) were used to study MS prevalence with respect to gender and age. The Framingham risk score (FRS) to predict the 10-year coronary heart disease (CHD) risk was calculated to compare the proportion of MS cases below or above 20%, according to both high and low waist circumference (WC) thresholds. Cohen's kappa coefficient (κ) was utilized to measure the degree of agreement between MS definitions. Results: The prevalence of the MS defined by the JIS was 28.0% and 24.7% when using the low (94/80) and the high (102/88) WC cut-off points, respectively. The prevalence was significantly higher in men than in women (OR = 2.6 and 2.3 for the low and high WC thresholds), as were all components of the MS except abdominal obesity measured by both thresholds. It also increased with age (OR values in age categories ranging from 2.7 to 28 when compared to the younger subjects for low WC and from 3.3 to 31 for the high WC cut-offs). The 10-year predicted risk of CHD by FRS did not depend on the threshold used. Globally, excellent agreement was observed between the three definitions of MS (κ= 0.89), in particular between JIS and IDF (κ = 0.93). Agreement was significantly higher in women than in men, and differed between age groups. Conclusion: Regardless of the definition used, the adult population of Luxembourg reveals a high MS prevalence. Our findings contribute to build evidence regarding the definitive construct of the MS, to help selecting the waist circumference thresholds for Europid populations, and to support the need to revise the guidelines for abdominal obesity levels.


Related Articles

  • A better parameter in predicting insulin resistance: Obesity plus elevated alanine aminotransferase. Ping-Hao Chen; Jong-Dar Chen; Yu-Cheng Lin; Arase, Yasuji // World Journal of Gastroenterology;11/28/2009, Vol. 15 Issue 44, p5598 

    AIM: To investigate the association of obesity and elevated alanine aminotransferase with insulin resistance and compare these factors with metabolic syndrome. METHODS: We enrolled a total of 1308 male workers aged from 22 to 63 years. Data was extracted from the workers' periodic health...

  • rs1501299 Polymorphism in the Adiponectin Gene and Their Association with Total Adiponectin Levels, Insulin Resistance and Metabolic Syndrome in Obese Subjects. de Luis, Daniel Antonio; Izaola, Olatz; de la Fuente, Beatriz; Primo, David; Fernandez Ovalle, Hilda; Romero, Enrique // Annals of Nutrition & Metabolism;Jan2017, Vol. 69 Issue 3/4, p226 

    Background and Aims: The aim of this study was to determine the association of single nucleotide polymorphism rs1501299 in the ADIPOQ gene with body weight, insulin resistance, serum adipokine levels and metabolic syndrome (MetS). Methods: The study involved a population of 1,007 adult obese...

  • Metabolic Syndrome and Insulin Resistance in Obese Prepubertal Children in Lebanon: A Primary Health Concern. Nasreddine, L.; Ouaijan, K.; Mansour, M.; Adra, N.; Sinno, D.; Hwalla, N. // Annals of Nutrition & Metabolism;Nov2010, Vol. 57 Issue 2, p135 

    Background/Aims: Ethnic-based associations between obesity and the metabolic syndrome (MS) have been suggested. The prevalence of MS in obese children was found to range between 13.9 and 48.8%, depending on the country of origin. This study was conducted to investigate the relationship between...

  • Cholecystectomy versus central obesity or insulin resistance in relation to the risk of nonalcoholic fatty liver disease: the third US National Health and Nutrition Examination Survey. Yue, Wenzhu; Sun, Xingxing; Du, Tingting // BMC Endocrine Disorders;9/2/2019, Vol. 19 Issue 1, pN.PAG 

    Background: Cholecystectomy, central obesity, and insulin resistance (IR) are established risk factors for nonalcoholic fatty liver disease (NAFLD). We aimed to examine the relative contributions and combined association of cholecystectomy and central obesity/IR with NAFLD risk. Methods: We...

  • NHANES data emphasized importance of diet and exercise in adolescent health.  // Infectious Diseases in Children;May2009, Vol. 22 Issue 5, p27 

    The article focuses on data from the National Health and Nutrition Examination Survey which indicated that promoting low sugar-sweetened beverage intake may improve overall health among adolescents and may help curb childhood obesity, insulin resistance and metabolic syndrome.

  • Predictors of the Incident Metabolic Syndrome in Adults. Palaniappan, Latha; Carnethon, Mercedes R.; Wang, Yun; Hanley, Anthony J. G.; Fortmann, Stephen P.; Haffner, Stephen M.; Wagenknecht, Lynne // Diabetes Care;Mar2004, Vol. 27 Issue 3, p788 

    To prospectively investigate predictors of the incident metabolic syndrome in nondiabetic adults. The best predictors of incident metabolic syndrome were waist circumference (odds ratio [OR] 1.7 [1.3–2.0] per 11 cm), HDL cholesterol (0.6 [0.4–0.7] per 15 mg/dl), and proinsulin (1.7...

  • Association between sleep duration and metabolic syndrome in a population-based study: Isfahan Healthy Heart Program. Najafian, Jamshid; Toghianifar, Nafiseh; Mohammadifard, Noushin; Nouri, Fatemeh // Journal of Research in Medical Sciences;Jun2011, Vol. 16 Issue 6, p801 

    BACKGROUND: Recent epidemiologic studies have found that self-reported sleep duration is associated with components of metabolic syndrome (MS) such as obesity, diabetes and hypertension. This relation may be under influence of regional factors in different regions of the world. The association...

  • Alanine Aminotransferase and Directly Measured Insulin Sensitivity in a Multiethnic Cohort. Hanley, Anthony J. G.; Wagenknecht, Lynne E.; Festa, Andreas; D'Agostino Jr., Ralph B.; Haffner, Steven M. // Diabetes Care;Jul2007, Vol. 30 Issue 7, p1819 

    OBJECTIVE-- The objective of the present analysis was to evaluate the association of alanine aminotransferase (ALT) with directly measured insulin sensitivity (Si) in a large, multiethnic cohort of U.S. adults and to determine whether ALT adds to existing metabolic risk definitions in...

  • Metabolic syndrome is an independent risk factor for breast cancer. Porto, Lakymê; Lora, Karla; Soares, Juliana; Costa, Laura // Archives of Gynecology & Obstetrics;Nov2011, Vol. 284 Issue 5, p1271 

    Objective: This study was aimed to assess the prevalence of metabolic syndrome in patients with breast cancer and the independent effect of metabolic syndrome on breast cancer risk. Methods: Eighty-one women aged 40-80 years with breast cancer and 81 controls of similar age were screened for...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics