1,000 structures and more from the MCSG

Lee, David; de Beer, Tjaart A. P.; Laskowski, Roman A.; Thornton, Janet M.; Orengo, Christine A.
January 2011
BMC Structural Biology;2011, Vol. 11 Issue 1, p1
Academic Journal
Background: The Midwest Center for Structural Genomics (MCSG) is one of the large-scale centres of the Protein Structure Initiative (PSI). During the first two phases of the PSI the MCSG has solved over a thousand protein structures. A criticism of structural genomics is that target selection strategies mean that some structures are solved without having a known function and thus are of little biomedical significance. Structures of unknown function have stimulated the development of methods for function prediction from structure. Results: We show that the MCSG has met the stated goals of the PSI and use online resources and readily available function prediction methods to provide functional annotations for more than 90% of the MCSG structures. The structure-to-function prediction method ProFunc provides likely functions for many of the MCSG structures that cannot be annotated by sequence-based methods. Conclusions: Although the focus of the PSI was structural coverage, many of the structures solved by the MCSG can also be associated with functional classes and biological roles of possible biomedical value.


Related Articles

  • BEReX: Biomedical Entity-Relationship eXplorer. Jeon, Minji; Lee, Sunwon; Lee, Kyubum; Tan, Aik-Choon; Kang, Jaewoo // Bioinformatics;Jan2014, Vol. 30 Issue 1, p135 

    Summary: Biomedical Entity-Relationship eXplorer (BEReX) is a new biomedical knowledge integration, search and exploration tool. BEReX integrates eight popular databases (STRING, DrugBank, KEGG, PhamGKB, BioGRID, GO, HPRD and MSigDB) and delineates an integrated network by combining the...

  • A new view concerning an actomyosin motor. Ishii, Y.; Yanagida, T. // Cellular & Molecular Life Sciences;Nov2002, Vol. 59 Issue 11, p1767 

    Offers a look at the mechanisms underlying the actomyosin motor. Techniques used in determining the movement, force and atomic structure of single myosin molecules; Graphical illustration of the processive movement of a single molecule of myosin VI; Causes of myosin movement.

  • Systems biology with a view. Mullard, Asher // Nature Reviews Molecular Cell Biology;Nov2006, Vol. 7 Issue 11, p792 

    The article reports on the Research Unit for Systems Biology, launched by the European Molecular Biology Laboratory and the Center for Genomic Regulation in Barcelona Biomedical Research Park, Barcelona, Spain, in September 2006. The article also features the statements by officials from EMBL...

  • Prophinder: a computational tool for prophage prediction in prokaryotic genomes. Gipsi Lima-Mendez; Jacques Van Helden; Ariane Toussaint; Raphaël Leplae // Bioinformatics;Mar2008, Vol. 24 Issue 6, p863 

    Summary: Prophinder is a prophage prediction tool coupled with a prediction database, a web server and web service. Predicted prophages will help to fill the gaps in the current sparse phage sequence space, which should cover an estimated 100 million species. Systematic and reliable predictions...

  • Stimuli Responsive Electrospun Fibres: Functions and Applications. ZHou Ying xue; Wang gang; Fan Xiao dong; Wang Xi; Kong Jie // Materials Science Forum;2014, Vol. 809-810, p737 

    Stimuli responsive electrospun fibers are obtained considerable attention as excellent functions and properties. An overview is given on recent advances made in the development from component to structure of electrospun fiber and applications in the aspects of physical and chemical stimuli. The...

  • VARI Makes Another Find. Emrich, Anne Bond // Grand Rapids Business Journal;3/7/2005, Vol. 23 Issue 10, p1 

    Presents the results of a study by H. Eric Xu and colleagues from the Can Andel Research Institute which gathered structural information on the constitutive androstanol receptor pocket. Use of a molecular X-ray analysis in observing the metabolic process on a molecular level; Overview of the...

  • Interaction of human serum albumin with 10-hydroxycamptothecin: spectroscopic and molecular modeling studies. Sun, Hui-Hui; Zhang, Jing; Zhang, Ye-Zhong; Yang, Li-Yun; Yuan, Li-Li; Liu, Yi // Molecular Biology Reports;May2012, Vol. 39 Issue 5, p5115 

    In this work, fluorescence spectroscopy in combination with circular dichroism spectroscopy and molecular modeling was employed to investigate the binding of 10-hydroxycamptothecin (HCPT) to human serum albumin (HSA) under simulative physiological conditions. The experiment results showed that...

  • Coordination Programming of Photo- and Electro-Functional Molecular Assemblies. Ryota Sakamoto // Annual International Conference on Chemistry, Chemical Engineeri;2014, p34 

    This presentation addresses our recent achievements in the creation of photo- and electro-functional molecular assemblies.

  • Structure watch.  // Nature Reviews Molecular Cell Biology;Dec2010, Vol. 11 Issue 12, p820 

    The article discusses studies related to molecular biology. It references the article "Template-free 13-protofilament microtubule-MAP assembly visualized at 8 Ã… resolution" by F. J. Fourniol and colleagues in the 2010 issue of "Journal of Cell Biology." It also highlights the study "NES...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics