Conservative Management of Pituitary Macroadenoma Contacting the Optic Apparatus

Ryu, Won Hyung A.; Tam, Samantha; Rotenberg, Brian; Labib, Mohamed Ahmed; Lee, Donald; Nicolle, David A.; Van Uum, Stan; Duggal, Neil
November 2010
Canadian Journal of Neurological Sciences;Nov2010, Vol. 37 Issue 6, p837
Academic Journal
Objectives: To describe the tumor characteristics and visual function in conservatively managed patients with non-functioning pituitary macroadenoma (NFMA) that contacted/compressed the visual pathway. Design: Retrospective case-series. Setting: Tertiary-care academic institution. Participants: Six patients with diagnosis of NFMA. Main Outcome: Visual function and radiological characteristics of the optic apparatus and pituitary tumor. Results: All patients had radiological evidence of optic apparatus compression but only one had visual field defect at the initial presentation. While two of the six patients developed visual field changes during followup (41±34.8 months), the patient with visual field defect at the time of diagnosis improved to normal vision. Conclusions: Select NFMAs that contact the optic apparatus, without visual dysfunction, may be managed with close ophthalmological and radiographic monitoring, depending on tumor and imaging characteristics. This may be of particular relevance in patients considered to have a high peri-operative risk, such as advanced age or significant co-morbidities.


Related Articles

  • Visual field assessment. Davies, Leon // Optometry Today;8/8/2015, Vol. 55 Issue 16, p48 

    A quiz concerning visual field assessment to test knowledge about visual pathway and indices generated by visual field instruments is presented.

  • Optimizing Contrast Sensitivity Perimetry for Clinical Use. Dul, Mitchell W. // Journal of Ophthalmic & Vision Research;Jan2013, Vol. 8 Issue 1, p74 

    The article presents information on the clinical use of perimetric testing for examining visual field abnormalities. It states that high test-retest variability affects conventional automated perimetry (CAP), which is inversely connected with retinal sensitivity. Images displaying contrast...

  • Matrix 24-2 Compares Favorably with SITA-Standard. Shaikh, Adam; Semes, Leo; Bartlett, Jimmy D.; Aiyuan Xie // Review of Optometry;3/15/2005 Supplement, Vol. 142, p3 

    Discusses the efficacy of the Humphrey Matrix 24-2 Standard Perimetry. Comparison with the Humphrey Field Analyzer 24-2 SITA-Standard Perimetry; Role of frequency doubling technology as a tool in visual field evaluation; Instruments' use of a different stimulus to measure retinal sensitivity;...

  • Patterns of visual field loss identified by unsupervised machine-learning. Guttman Krader, Cheryl; Bowd, Christopher // Ophthalmology Times;11/1/2014, Vol. 39 Issue 20, p22 

    The article discusses a study by Christopher Bowd et al as of November 2014 that highlights the capability of the variational Bayesian independent component analysis mixture model (VIM) in determining binocular patterns of glaucomatous defects in monocular standard automated perimetry visual...

  • Probabilistic MRI Tractography of the Optic Radiation Using Constrained Spherical Deconvolution: A Feasibility Study. Lim, Jeremy C.; Phal, Pramit M.; Desmond, Patricia M.; Nichols, Andrew D.; Kokkinos, Chris; Danesh-Meyer, Helen V.; Kaye, Andrew H.; Moffat, Bradford A. // PLoS ONE;Mar2015, Vol. 10 Issue 3, p1 

    Background and Purpose: Imaging the optic radiation (OR) is of considerable interest in studying diseases affecting the visual pathway and for pre-surgical planning of temporal lobe resections. The purpose of this study was to investigate the clinical feasibility of using probabilistic...

  • Effect of different stimulus configurations on the visual evoked potential (VEP). Yadav, Naveen; Ludlam, Diana; Ciuffreda, Kenneth // Documenta Ophthalmologica;Jun2012, Vol. 124 Issue 3, p177 

    The purpose of this study was to assess changes in the response profile of the pattern visual evoked potential (VEP) using three stimulus configurations simulating visual-field scotomas: central circular and central blank fields increasing incrementally in diameter from 1° to 15°,...

  • Pattern visual evoked potentials in Japanese patients with multiple sclerosis without history of visual pathway involvement. Atsushi Mizota; Noriko Asaumi; Michihiko Takasoh; Emiko Adachi-Usami // Documenta Ophthalmologica;Sep2007, Vol. 115 Issue 2, p105 

    Abstract  A delay of the peak latency of the pattern visual evoked cortical potentials (pVEP) is accepted as one of the paraclinical evidence for a diagnosis of multiple sclerosis (MS). The purpose of this study was to evaluate the pVEPs in Japanese patients with MS without a...

  • How much is the brain involved in glaucoma? Alm, A. // British Journal of Ophthalmology;Jun2006, Vol. 90 Issue 6, p663 

    The article comments on N. Gupta and colleagues' paper about the involvement of the brain in glaucoma. The researchers present the findings of an autopsy of a patient with bilateral open angle glaucoma with severe visual field loss in both eyes. The case study reveals a neural degeneration in...

  • Evaluation of a combined index of optic nerve structure and function for glaucoma diagnosis. Boland, Michael V.; Quigley, Harry A. // BMC Ophthalmology;2011, Vol. 11 Issue 1, p6 

    Background: The definitive diagnosis of glaucoma is currently based on congruent damage to both optic nerve structure and function. Given widespread quantitative assessment of both structure (imaging) and function (automated perimetry) in glaucoma, it should be possible to combine these...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics