TITLE

Effect of erythropoietin levels on mortality in old age: the Leiden 85-plus Study

AUTHOR(S)
den Elzen, Wendy P. J.; Willems, Jorien M.; Westendorp, Rudi G. J.; de Craen, Anton J. M.; Blauw, Gerard Jan; Ferrucci, Luigi; Assendelft, Willem J. J.; Gussekloo, Jacobijn
PUB. DATE
December 2010
SOURCE
CMAJ: Canadian Medical Association Journal;12/14/2010, Vol. 182 Issue 18, p1953
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The production of erythropoietin is triggered by impaired oxygen delivery to the kidney, either because of anemia or hypoxemia. High erythropoietin levels have been shown to predict the risk of death among patients with chronic heart failure. We investigated the prognostic value of elevated erythropoietin levels on mortality among very elderly people in the general population. Methods: The Leiden 85-plus Study is a population-based prospective follow-up study involving 599 people aged 85 years in Leiden, the Netherlands, enrolled between September 1997 and September 1999. Erythropoietin levels were determined at age 86. For this analysis, we included 428 participants with a creatinine clearance of at least 30 mL/min. Mortality data, recorded until Feb. 1, 2008, were obtained from the municipal registry. Results: During follow-up, 324 (75.7%) participants died. Compared with participants whose erythropoietin levels were in the lowest tertile (reference group), those whose levels were in the middle tertile had a 25% increased risk of death (hazard ratio [HR] 1.25, 95% confidence interval [CI] 0.95--1.64), and those whose levels were in the highest tertile had a 73% increased risk (HR 1.73, 95% CI 1.32-2.26) (p value for trend < 0.01). The association between erythropoietin levels and mortality remained largely unchanged after we adjusted for sex, creatinine clearance, hemoglobin level, comorbidity, smoking status and C-reactive protein level, and was similar for deaths from cardiovascular and noncardiovascular causes. Interpretation: Among people aged 85 years and older, elevated erythropoietin levels were associated with an increased risk of death, independent of hemoglobin levels.
ACCESSION #
57855008

 

Related Articles

  • Hypoxia/fatigue-induced degradation of troponin I and troponin C: new insights into physiologic muscle fatigue. de Paula Brotto, Marco; Van Leyen, Sheila Andreatta; Brotto, Leticia S.; Jin, Jian-Ping; Nosek, Christopher M.; Nosek, Thomas M. // Pflugers Archiv European Journal of Physiology;Aug2001, Vol. 442 Issue 5, p738 

    Conditions such as respiratory failure and cardiopulmonary arrest can expose the diaphragm to hypoxemia. In skeletal muscles, fatiguing stimulation renders muscles hypoxic, which has long been known to dramatically reduce muscle function. We have previously demonstrated that fatiguing...

  • How do patients with heart failure with preserved ejection fraction die? Chan, Michelle M.Y.; Lam, Carolyn S.P. // European Journal of Heart Failure;Jun2013, Vol. 15 Issue 6, p604 

    Understanding how patients with heart failure with preserved ejection fraction (HFPEF) die provides insight into the natural history and pathophysiology of this complex syndrome, thereby allowing better prediction of response to therapy in designing clinical trials. This review summarizes the...

  • cardiopulmonary arrest.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p370 

    A definition of the term "cardiopulmonary arrest" also known as cardia arrest is presented.

  • β blocker treatment is associated with improvement in renal function and anaemia in patients with heart failure. Khan, W.; Deepak, S. M.; Coppinger, T.; Waywell, C.; Borg, A.; Harper, L.; Williams, S. G.; Brooks, N. H. // Heart;Dec2006, Vol. 92 Issue 12, p1856 

    The article provides information on the effect of βblocker treatment associated with improvement in renal function and anemia in patients with heart failure. It has been explained that chronic renal impairment and anemia are common comorbidities associated with congestive heart failure. This...

  • How to reduce sudden cardiac death in patients with renal failure. de Bie, Mihály K.; Buiten, Maurits S.; Rabelink, Ton J.; Jukema, J. Wouter // Heart;Feb2012, Vol. 98 Issue 4, p335 

    The article discusses the prevention of sudden cardiac death (SCD) in patients with chronic kidney disease (CKD). It summarizes the mechanisms associated with SCD in patients with CKD, including ischaemic heart disease, vascular calcification, and increased overactivity. It also discusses...

  • Fatal Cerebral Hypoxemia after Cardiac Arrest. Kelsen, Jesper; Obel, Annette // New England Journal of Medicine;2/27/2003, Vol. 348 Issue 9, p817 

    Presents observations about a case of fatal cerebral hypoxemia after cardiac arrest. How electrocardiography revealed signs of acute inferior myocardial ischemia and sinus tachycardia; Speculation that the symptoms suggest anoxic encephalopathy; Findings during the neurologic examination.

  • ADAPTATION TO PERIODIC PRESSURE CHAMBER HYPOXIA AND ITS INFLUENCE ON SYSTOLIC AND DIASTOLIC FUNCTIONS IN CHRONIC HEART FAILURE. Dmitrieva, M. K. // Saratov Journal of Medical Scientific Research / Saratovskii Nau;Apr-jun2012, Vol. 8 Issue 2, p247 

    Research objective is to determine the influence of adaptation method to periodic pressure chamber hypoxia on dynamics of systolic and diastolic functions of myocardium in patients with early stages of chronic heart failure. Materials and Methods: 100 men with post-infarction cardiosclerosis at...

  • Secondary Affective Disorder in Survivor of Cardiac Arrest A Case Report. Kumar, Anil; Agarwal, Meena // British Journal of Psychiatry;Dec88, Vol. 153, p836 

    A case of hypomania following cerebral anoxia due to cardiac arrest is reported. The concept of secondary affective disorder is reviewed and the need for early recognition of such cases is emphasised.

  • Results From Extrapleural Clipping of a Patent Ductus Arteriosus in Seriously Ill Preterm Infants. Demirturk, Orhan; Güvener, Murat; Coşkun, Isa; Tünel, Hüseyin // Pediatric Cardiology;Dec2011, Vol. 32 Issue 8, p1164 

    Minithoracotomy for extrapleural closure of the patent ductus arteriosus (PDA) in seriously ill patients offers a fast and less invasive alternative to conventional transpleural ductal closure. This study reports the immediate postoperative clinical outcomes for 24 extrapleurally clipped...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics