Coccidioidomycosis in African Americans

Ruddy, Barbara E.; Mayel, Anita P.; Ko, Marcia G.; Labonte, Helene R.; Borovansky, Jill A.; Boroff, Erika S.; Blair, Janis E.
January 2011
Mayo Clinic Proceedings;Jan2011, Vol. 86 Issue 1, p63
Academic Journal
Coccidloidomycosis is caused by Coccidloldes species, a fungus endemic to the desert regions of the southwestern United States, and is of particular concern for African Americans. We performed a PubMed search of the English-language medical literature on coccidioldomycosis in African Americans and summarized the pertinent literature. Search terms were coccidioldomycosis, Coccldloldes, race, ethnicity, African, black, and Negro. The proceedings of the national and international coccidioldomycosis symposia were searched. All relevant articles and their cited references were reviewed; those with epidemiological, immunologic, clinical, and therapeutic data pertaining to coccidloidomycosis in African Americans were included in the review. Numerous studies documented an increased predilection for severe coccidloldai infections, coccidioldomycosis-related hospitalizations, and extrapulmonary dissemination in persons of African descent; however, most of the published studies are variably problematic. The immunologic mechanism for this predilection is unclear. The clinical features and treatment recommendations are summarized. Medical practitioners need to be alert to the possibility of coccidloldomycosls in persons with recent travel to or residence in an area where the disease Is endemic.


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