The Association of Active Cancer With Venous Thromboembolism Location: A Population-Based Study

Tafur, Alfonso J.; Kalsi, Henna; Wysokinski, Waldemar E.; McBane, Robert D.; Ashrani, Aneel A.; Marks, Randolph S.; Crusan, Daniel J.; Petterson, Tanya M.; Bailey, Kent R.; Heit, John A.
January 2011
Mayo Clinic Proceedings;Jan2011, Vol. 86 Issue 1, p25
Academic Journal
OBJECTIVE: To test active cancer for an association with venous thromboembolism (VTE) location. PATIENTS AND METHODS: Using the resources of the Rochester Epidemiology Project, we identified all Olmsted County, MN, residents with incident VIE during the 35-year period 1966-2000 (N=3385). We restricted analyses to residents with objectively diagnosed VIE during the 17-year period from January 1, 1984, to December 31, 2000 (N=1599). For each patient, we reviewed the complete medical records in the community for patient age, gender, and most recent body mass index at VIE onset; VIE event type and location; and previously identified independent VIE risk factors (ie, surgery, hospitalization for acute medical illness, active cancer, leg paresis, superficial venous thrombosis, and varicose veins). Using logistic regression we tested active cancer for an association with each of 4 symptomatic VIE locations (arm or intra-abdominal deep venous thrombosis [VI], intra-abdominal DVI, pulmonary embolism, and bilateral leg DVI), adjusted for age, gender, body mass index, and other VTE risk factors. RESULTS: In multivariate analyses, active cancer was independently associated with arm or intra-abdominal DVI (odds ratio [OR], 1.76; P=.01), Intra-abdominal DVI (OR, 2.22; P=.004), and bilateral leg DVI (OR, 2.09; P=.02), but not pulmonary embolism (OR, 0.93). CONCLUSION: Active cancer is associated with VIE location. Location of VIE may be useful in decision making regarding cancer screening.


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