Association of ghrelin and leptin with reproductive hormones in constitutional delay of growth and puberty

El-Eshmawy, Mervat M.; Abdel Aal, Ibrahim A.; El hawary, Amany K.
January 2010
Reproductive Biology & Endocrinology;2010, Vol. 8, p153
Academic Journal
Background: Constitutional delay of growth and puberty (CDGP) is a variation of the onset and timing of pubertal development without a defined endocrine abnormality. Recently published studies indicate that leptin and ghrelin play a role in puberty initiation and progress. They have been implicated in regulation of GnRH secretion, with ghrelin having inhibitory and leptin, facilitatory effects. We hypothesized that elevated ghrelin and reduced leptin concentrations could be implicated in altering the tempo of puberty in adolescents with CDGP. So in the current study we evaluate variations in leptin and ghrelin levels in adolescent boys with CDGP, the relationships between both hormones and reproductive hormones including LH, FSH and testosterone were also evaluated. Methods: The study enrolled 23 adolescent boys with CDGP and 20 healthy controls matched for age and sex. Weight, height, BMI, testicular volume, bone age, bone age delay, serum FSH, LH, testosterone, leptin and ghrelin were assessed. Results: Adolescent boys with CDGP had significantly lower leptin and higher ghrelin than normal controls. Leptin was positively correlated with BMI, bone age, testicular volume, FSH, LH and testosterone and negatively correlated with delayed bone age and ghrelin. Ghrelin was negatively correlated with BMI, bone age, testicular volume, FSH, LH and testosterone. With multiple regression analysis BMI, FSH, LH, testosterone and ghrelin remained independently correlated with leptin while BMI, LH and testosterone remained independently correlated with ghrelin. Conclusion: Elevated serum ghrelin and decreased leptin concentrations and their associations with reproductive hormones may explain the sexual immaturity in adolescent boys with CDGP.


Related Articles

  • Adipocytokine and Ghrelin Responses to Acute Exercise and Sport Training in Children During Growth and Maturation. Jürimäe, Jaak // Pediatric Exercise Science;Nov2014, Vol. 26 Issue 4, p392 

    Physical exercise is known to regulate energy balance. Important to this regulatory system is the existence of several peptides that communicate the status of body energy stores to the brain and are related to the body fatness including leptin, adiponectin and ghrelin. These hormones assist in...

  • Hormonal MINEFIELD.  // Cleo;Aug2015, p108 

    The article discusses hormones that can contribute to weight loss. Topics covered include the role of insulin in fat control, fat-burning properties of human growth hormone (HGH) and testosterone, and appetite suppression by leptin and ghrelin. Also mentioned are the digestive hormone...

  • Antibody design: Hormone-CDR fusions enhance hormone efficacy. Crunkhorn, Sarah // Nature Reviews Drug Discovery;Mar2015, Vol. 14 Issue 3, p166 

    The article offers news briefs on the study which showed that fused human growth hormone (GH) and human leptin enhance hormone efficacy.

  • Role of Ghrelin and Leptin in Predicting the Severity of Acute Pancreatitis. Mustafa Kerem; Abdulkadir Bedirli; Hatice Pasaoglu; Cigdem Unsal; Tonguc Yilmaz; Ebru Ofluoglu; Tevfik Sahin // Digestive Diseases & Sciences;Apr2007, Vol. 52 Issue 4, p950 

    Abstract  Ghrelin and leptin are the hormones that influence endocrine and exocrine functions of the pancreas and regulate feeding behaviors and energy metabolism. The aim of this study was to investigate the levels of ghrelin and leptin in pancreatitis of different severities and the...

  • Sleep Duration and Levels of Hormones That Influence Hunger. Spiegel, K.; Tasali, E.; Penev, P.; Van Cauter, E. // Annals of Internal Medicine;12/7/2004, Vol. 141 Issue 11, pI52 

    The article presents queries related to the sleep duration and levels of hormones that influence hunger. Hormones are substances in the body that help to regulate body processes. Researchers have been learning a lot about the hormones that help to regulate hunger. Two of these hormones are...

  • Adipokines and ghrelin in gastric cancer cachexia. Kerem, Mustafa; Ferahkose, Zafer; Yilmaz, Utku Tonguc; Pasaoglu, Hatice; Ofluoglu, Ebru; Bedirli, Abdulkadir; Salman, Bulent; Sahin, Tevfik Tolga; Akin, Murat; Shingo Tsuji; Malekzadeh, Reza // World Journal of Gastroenterology;6/21/2008, Vol. 14 Issue 23, p3633 

    AIM: TO investigate the roles of the adipocytokines, ghrelin and leptin in gastric cancer cachexia. METHODS: Resistin, ghrelin, leptin, adiponectin, insulin and insulin-like growth factor (IGF- I ), were measured in 30 healthy subjects, and 60 gastric cancer patients of which 30 suffered from...

  • Brief Communication: Sleep Curtailment in Healthy Young Men Is Associated with Decreased Leptin Levels, Elevated Ghrelin Levels, and Increased Hunger and Appetite. Spiegel, Karine; Tasali, Esra; Penev, Plamen; Van Cauter, Eve // Annals of Internal Medicine;12/7/2004, Vol. 141 Issue 11, p846 

    Background: Total sleep deprivation in rodents and in humans has been associated with hyperphagia. Over the past 40 years, self-reported sleep duration in the United States has decreased by almost 2 hours. Objective: To determine whether partial sleep curtailment, an increasingly prevalent...

  • Coronary Calcification and Hormones. Koulaouzidis, George; Henein, Michael // Angiology;Oct2011, Vol. 62 Issue 7, p554 

    The pathogenesis of coronary artery calcification and its role in atherogenesis has not been completely understood but is a new focus of interest in experimental and clinical research. Various bioactive substances, including hormones, have been implicated in the process of arterial...

  • Hormonal Regulation of Hepatic Drug-Metabolizing Enzyme Activity During Adolescence. Kennedy, M. J. // Clinical Pharmacology & Therapeutics;Dec2008, Vol. 84 Issue 6, p662 

    Activities of drug-metabolizing enzymes (DMEs) are known to change throughout the course of physical and sexual maturation, with the greatest variability noted during infancy and adolescence. The mechanisms responsible for developmental regulation of DME are currently unknown. However, the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics