Neoadjuvant and adjuvant therapy for renal cell carcinoma: a new treatment paradigm for locally advanced and metastatic disease in the era of targeted therapy

Krieger, Laurence; Kristeleit, Hartmut; Chowdhury, Simon
September 2010
Advances in Oncology;2010, Vol. 5 Issue 3, p10
Academic Journal
The article discusses the relevance of neoadjuvant and adjuvant systematic therapies to renal cell carcinoma assessment. It enumerates several possible advantages of the neoadjuvant therapy including its responses in the primary tumour, the preservation of renal function in nephronsparing surgery and the availability of tissues. Results of the Phase III studies of neodajuvant setting are claimed promising while the adjuvant therapy is accordingly subject to Phase III clinical trials.


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