TITLE

Direct Conversion of Skin Cells into Blood: Alchemy or Science?

AUTHOR(S)
King, Katherine Y.; Goodell, Margaret A.
PUB. DATE
February 2011
SOURCE
Molecular Therapy;Feb2011, Vol. 19 Issue 2, p227
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents the methods of generating blood replacements from skin cells. It states that the combined exogenous expression of pluripotency factors can present the characteristics of pluripotent stem cells of a distinguished adult cell, while enhancing the ability of embryonic stem cells in differentiating the hematopoietic cells can generate blood replacement. It also mentions that transplantations is the gold-standard test for hematopoietic stem cell.
ACCESSION #
57749795

 

Related Articles

  • GATA-2 and GATA-2/ER display opposing activities in the development and differentiation of blood progenitors. Kitajima, Kenji; Masuhara, Masaaki; Era, Takumi; Enver, Tariq; Nakano, Toru // EMBO Journal;6/15/2002, Vol. 21 Issue 12, p3060 

    GATA-2 is a zinc finger transcription factor essential for the development of hematopoiesis. While GATA-2 is generally considered to play an important role in the biology of hematopoietic stem and progenitor cells, its function within these compartments is not welt understood. Here we have...

  • Stem Cells, Including a Population of Very Small Embryonic-Like Stem Cells, are Mobilized Into Peripheral Blood in Patients After Skin Burn Injury. Drukała, Justyna; Paczkowska, Edyta; Kucia, Magda; Młyńska, Elżbieta; Krajewski, Andrzej; Machaliński, Bogusław; Madeja, Zbigniew; Ratajczak, Mariusz // Stem Cell Reviews & Reports;Mar2012, Vol. 8 Issue 1, p184 

    Background: Developmentally early cells, including hematopoietic stem progenitor cells (HSPCs), as well as very small embryonic-like stem cells (VSELs), are mobilized into peripheral blood (PB) in response to tissue and organ injury (e.g., heart infarct or stroke). Objective: We seek to...

  • Circulating hematopoietic stem cell count is a valuable predictor of prematurity complications in preterm newborns. Kotowski, Maciej; Safranow, Krzysztof; Kawa, Miłosz P.; Lewandowska, Joanna; Kłos, Patrycja; Dziedziejko, Violetta; Paczkowska, Edyta; Czajka, Ryszard; Celewicz, Zbigniew; Rudnicki, Jacek; Machaliński, Bogusław // BMC Pediatrics;2012, Vol. 12 Issue 1, p1 

    Background: The frequency of preterm labour has risen over the last few years. Hence, there is growing interest in the identification of markers that may facilitate prediction and prevention of premature birth complications. Here, we studied the association of the number of circulating stem cell...

  • Applications of Human Umbilical Cord Blood Cells in Central Nervous System Regeneration. Herranz, Antonio S.; Gonzalo-Gobernado, Rafael; Reimers, Diana; Asensio, Maria J.; Rodríguez-Serrano, Macarena; Bazán, Eulalia // Current Stem Cell Research & Therapy;Mar2010, Vol. 5 Issue 1, p17 

    In recent decades, there has been considerable amount of information about embryonic stem cells (ES). The dilemma facing scientists interested in the development and use of human stem cells in replacement therapies is the source of these cells, i.e. the human embryo. There are many ethical and...

  • Prospects of Embryonic Stem Cells in Treatment of Hematopoietic Disorders. Srivastava, Anand S.; Malhotra, Rakesh; Esmaeli-Azad, Babak; Lane, Tom; Carrier, Ewa // Current Pharmaceutical Biotechnology;Oct2007, Vol. 8 Issue 5, p305 

    Cellular therapies derived from embryonic stem (ES) cells have gained a renewed interest with the experimental demonstration that an embryonic stem cell lines can be established from human blastocyst-stage embryos and prompted to differentiate into almost all types of cells present in the body...

  • Dynamic regulation of epigenomic landscapes during hematopoiesis. Abraham, Brian J.; Kairong Cui; Qingsong Tang; Keji Zhao // BMC Genomics;2013, Vol. 14 Issue 1, p1 

    Background: Human blood develops from self-renewing hematopoietic stem cells to terminal lineages and necessitates regulator and effector gene expression changes; each cell type specifically expresses a subset of genes to carry out a specific function. Gene expression changes coincide with...

  • Use of Human Embryonic Stem Cells to Understand Hematopoiesis and Hematopoietic Stem Cell Niche. Islam, Mohammad Saiful; Ni, Zhenya; Kaufman, Dan S. // Current Stem Cell Research & Therapy;Sep2010, Vol. 5 Issue 3, p245 

    Intensive research of hematopoiesis using human embryonic stem cells (hESC) as a unique starting cell population has enabled differentiation and isolation of diverse hematopoietic cell lineages. However, there has been only limited success in derivation of hematopoietic stem cells (HSCs) capable...

  • OP9 Bone Marrow Stroma Cells Differentiate into Megakaryocytes and Platelets. Matsubara, Yumiko; Ono, Yukako; Suzuki, Hidenori; Arai, Fumio; Suda, Toshio; Murata, Mitsuru; Ikeda, Yasuo // PLoS ONE;Mar2013, Vol. 8 Issue 3, p1 

    Platelets are essential for hemostatic plug formation and thrombosis. The mechanisms of megakaryocyte (MK) differentiation and subsequent platelet production from stem cells remain only partially understood. The manufacture of megakaryocytes (MKs) and platelets from cell sources including...

  • Peripheral Blood Stem Cells: Phenotypic Diversity and Potential Clinical Applications. Zhang, Yichi; Huang, Bing // Stem Cell Reviews & Reports;Sep2012, Vol. 8 Issue 3, p917 

    A small proportion of cells in peripheral blood are actually pluripotent stem cells. These peripheral blood stem cells (PBSCs) are thought to be heterogeneous and could be exploited for a variety of clinical applications. The exact number of distinct populations is unknown. It is likely that...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics