TITLE

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF RISPERIDONE AND TRIHEXYPHENIDYL HYDROCHLORIDE IN TABLET DOSAGE FORMS

AUTHOR(S)
Patel, Dhara; Patel, Jayvadan
PUB. DATE
September 2010
SOURCE
International Journal of Pharmaceutical Sciences Review & Resear;Sep2010, Vol. 4 Issue 3, p85
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A binary mixture of Risperidone (RIS) and Trihexyphenidyl hydrochloride (THP) was determined using reversed-phase liquid chromatography method using methanol: acetonitrile: 0.05 M phosphate buffer (pH 3.7) (60:30:10, v/v/v) pumped at a flow rate of 1.0 ml/min. Quantification was achieved with ultraviolet detection at 230 nm over concentration ranges of 0.5-5.0 and 1.0-10.0 μg/ml; mean accuracies were 100.55±0.64 and 100.75±0.81%, respectively. The method was successively applied to tablet dosage forms as no chromatographic interferences from the tablet excipients were observed. The method retained its accuracy and precision when the standard addition technique was applied.
ACCESSION #
57621855

Tags: RISPERIDONE;  LIQUID chromatography;  PHOSPHATES;  ACETONITRILE;  METHANOL;  CHROMATOGRAPHIC analysis;  DRUGS -- Dosage

 

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