Patel, Dhara; Patel, Jayvadan
September 2010
International Journal of Pharmaceutical Sciences Review & Resear;Sep2010, Vol. 4 Issue 3, p85
Academic Journal
A binary mixture of Risperidone (RIS) and Trihexyphenidyl hydrochloride (THP) was determined using reversed-phase liquid chromatography method using methanol: acetonitrile: 0.05 M phosphate buffer (pH 3.7) (60:30:10, v/v/v) pumped at a flow rate of 1.0 ml/min. Quantification was achieved with ultraviolet detection at 230 nm over concentration ranges of 0.5-5.0 and 1.0-10.0 μg/ml; mean accuracies were 100.55±0.64 and 100.75±0.81%, respectively. The method was successively applied to tablet dosage forms as no chromatographic interferences from the tablet excipients were observed. The method retained its accuracy and precision when the standard addition technique was applied.


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