Cell signalling: Weighing up TGFβ signals

Schuldt, Alison
February 2011
Nature Reviews Molecular Cell Biology;Feb2011, Vol. 12 Issue 2, p76
Academic Journal
The article offers information on the transforming growth factor-B (TGFB) signalling in cells which is directly affected by triaminoguanidinum (TAZ) and yes-associated proteins (YAP) in the Hippo pathway.


Related Articles

  • Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4. Morén, Anita; Itoh, Susumu; Moustakas, Aristidis; ten Dijke, Peter; Heldin, Carl-Henrik // Oncogene;9/7/2000, Vol. 19 Issue 38, p4396 

    Smads, the intracellular effectors of transforming growth factor-β (TGF-β) family members, are somatically mutated at high frequency in particular types of human cancers. Certain of these mutations affect the Smad amino-terminal domain, which, in the case of Smad3 and Smad4, binds DNA. We...

  • Distinct endocytic pathways regulate TGF-B receptor signalling and turnover. Di Guglielmo, Gianni M.; Le Roy, Christine; Goodfellow, Anne F.; Wrana, Jeffrey L. // Nature Cell Biology;May2003, Vol. 5 Issue 5, p410 

    Endocytosis of cell surface receptors is an important regulatory event in signal transduction. The transforming growth factor β (TGF-β) superfamily signals to the Smad pathway through heteromeric Ser-Thr kinase receptors that are rapidly internalized and then downregulated in a...

  • Mechanism of activation of the TGF-beta receptor. Wrana, Jeffrey L.; Attisano, Liliana // Nature;8/4/1994, Vol. 370 Issue 6488, p341 

    Determines the role of transforming growth factor-beta (TGF-beta) molecules in signal transduction. Phosphorylation state of TGF-beta type II receptor in epithelial cells; Receptors I and II phosphorylation; Receptor complexes (32P)-labelled in vivo.

  • Transcriptional Regulation by Smads: Crosstalk between the TGF-β and Wnt Pathways. Letamendia, Ainhoa; Labbe, Etienne; Attisano, Liliana // Journal of Bone & Joint Surgery, American Volume;Mar2001 Supplement 1 Part 1, Vol. 83-A, pS1-31 

    Background: Several studies have shown that cooperation between transforming growth factor beta (TGF-β) and Wnt/wingless signaling pathways plays a role in controlling certain developmental events. These factors elicit their biological effects through distinct pathways in which TGF-β and...

  • TGF-b and the Smad signal transduction pathway. Mehra, Arun; Wrana, Jeffrey L // Biochemistry & Cell Biology;Oct2002, Vol. 80 Issue 5, p605 

    Transforming growth factor β (TGF-β) superfamily members are important regulators of many diverse developmental and homeostatic processes and disruption of their activity has been implicated in a variety of human diseases ranging from cancer to chondrodysplasias and pulmonary hypertension....

  • Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β. Abreu, José G.; Ketpura, Nan I.; Reversade, Bruno; De Robertis, E. M. // Nature Cell Biology;Aug2002, Vol. 4 Issue 8, p599 

    Connective-tissue growth factor (CTGF) is a secreted protein implicated in multiple cellular events including angiogenesis, skeletogenesis and wound healing. It is a member of the CCN family of secreted proteins, named after CTGF, cysteine-rich 61 (CYR61), and nephroblastoma overexpressed (NOV)...

  • Role of Transforming Growth Factor-Beta Signaling in Cancer. de Caestecker, Mark P.; Piek, Ester // JNCI: Journal of the National Cancer Institute;09/06/2000, Vol. 92 Issue 17, p1388 

    Focuses on a prominent pathway of signaling from the transforming growth factor (TGF)-beta receptors involving Smad proteins, a family of intracellular mediators, which plays a complex role in carcinogenesis. Mechanisms of regulation of certain TGF-beta genes by the Smad-signaling pathway; Role...

  • Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β1 signalling. Mutlu, Gökhan M.; Budinger, G. R. Scott; Minghua Wu; Lam, Anna P.; Zirk, Aaron; Rivera, Stephanie; Urich, Daniela; Chiarella, Sergio E.; Go, Leonard H. T.; Ghosh, Asish K.; Selman, Moises; Pardo, Annie; Varga, John; Kamp, David W.; Chandel, Navdeep S.; Sznajder, Jacob Iasha; Jain, Manu // Thorax;Feb2012, Vol. 67 Issue 2, p139 

    Background The development of organ fibrosis after injury requires activation of transforming growth factor β1 which regulates the transcription of profibrotic genes. The systemic administration of a proteasomal inhibitor has been reported to prevent the development of fibrosis in the liver,...

  • The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-ß receptors. Lo, Roger S.; Ye-Guang Chen; Yigong Shi; Pavletich, Nikola P.; Massague, Joan // EMBO Journal;2/15/98, Vol. 17 Issue 4, p996 

    Signal transduction specificity in the transforming growth factor-β(TGFβ) system is determined by ligand activation of a receptor complex which then recruits and phosphorylates a subset of SMAD proteins including Smads 1 and 2. These then associate with Smad4 and move into the nucleus...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics