The Effect of Pleural Adhesions on Pediatric Cystic Fibrosis Patients Undergoing Lung Transplantation

Bremner, Ross M.; Woo, Marilyn S.; Arroyo, Hector; Nigro, John J.; Horn, Monica V.; Wells, Winfield J.; Barr, Mark; Starnes, Vaughn A.
December 2001
American Surgeon;Dec2001, Vol. 67 Issue 12, p1136
Academic Journal
The degree of pleural scarring complicating cystic fibrosis (CF) lung disease is thought to impact on the outcome of adult lung transplantation. This has not been previously studied in the pediatric population. We studied all patients undergoing lung transplantation at Children's Hospital Los Angeles from 1993 through 2000. Operative times, grade of pleural scarring, blood product transfusion requirements, and perioperative mortality were compared for patients with cystic fibrosis (35) versus those without this diagnosis (11). Patients with CF were slightly older (14.7 +/3.8 vs 10.6 +/- 5.6 years; P = 0.01) but had similar weights (34.8 +/- 8.7 vs 34.4 +/- 12.3 kg). The degree of pleural scarring was greater in the CF group but was only severe in four patients. Scarring did not impact on operative times (237 +/- 46 vs 219 +/- 39 minutes; P = 0.22) or cardiopulmonary bypass times (127 +/- 40 vs 133 +/- 49 minutes). Total perioperative blood requirements for the two groups were similar (35.6 +/- 14.9 vs 42.8 +/- 76.7 cm[sup 3]/kg; P = 0.82). Pleural scarring in the pediatric CF patients undergoing lung transplantation is only severe in a minority of patients. It does not increase duration of operation nor blood transfusion requirements. CT scanning is consequently unnecessary in the preoperative workup of CF patients being evaluated for transplantation. CF patients undergoing transplantation have perioperative outcomes similar to those of noncystic patients.


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