Donor predicted post-operative forced expiratory volume in one second predicts recipients’ best forced expiratory volume in one second following size-reduced lung transplantation

Inci, Ilhan; Irani, Sarosh; Kestenholz, Peter; Benden, Christian; Boehler, Annette; Weder, Walter
January 2011
European Journal of Cardio-Thoracic Surgery;Jan2011, Vol. 39 Issue 1, p115
Academic Journal
Abstract: Objective: The limited number of available grafts is one of the major obstacles of lung transplantation. Size-reduced lung transplantation allows the use of oversized grafts for small recipients. Optimal lung size matching is vital to achieve best functional outcome and avoid potential problems when using oversized grafts. We hypothesise that donor-predicted postoperative forced expiratory volume in 1s (ppoFEV1) correlates with the recipient best FEV1 after size-reduced lung transplant, being useful for the estimation of function outcome. Methods: All patients undergoing size-reduced or standard bilateral lung transplantation were included (1992–2007). Donor ppoFEV1 was calculated and corrected with respect to size reduction and correlated with recipient measured best FEV1 post-transplant. In addition, pre- and postoperative clinical data including surgical complications and outcome of all size-reduced lung transplant recipients were compared with standard lung transplant recipients. Results: A total of 61 size-reduced lung transplant recipients (lobar transplants, n =20; anatomic or non-anatomic resection, n =41) were included and compared to 145 standard transplants. The mean donor–recipient height difference was statistically significant between the two groups (p =0.0001). The mean donor ppoFEV1 was comparable with recipient best FEV1 (2.7±0.6 vs 2.6±0.7 l). There was a statistically significant correlation between donor ppoFEV1 and recipient best FEV1 (p =0.01, r =0.688). The 30-day mortality rate and 3-month, 1- and 5-year survival rates were comparable between the two groups. Conclusions: In size-reduced lung transplantation, postoperative recipient best FEV1 could be predicted from donor-calculated and corrected FEV1 with respect to its size reduction. Compared to standard lung transplantation, equivalent morbidity, mortality and functional results could be obtained after size-reduced lung transplantation.


Related Articles

  • D-MELD does not predict post-liver transplantation survival: a single-center experience from Brazil. Costabeber, Ane M.; Lionço, Lívia C.; Marroni, Cláudio; Zanotelli, Maria L.; Cantisani, Guido; Brandão, Ajácio // Annals of Hepatology: Official Journal of the Mexican Associatio;Nov/Dec2014, Vol. 13 Issue 6, p781 

    Background. The D-MELD score was designed to prevent donor-recipient matches with a high risk of unfavorable outcome. The main objective of the present study was to assess the predictive value of the D-MELD score for 1-month and 3-month post-transplant mortality in a cohort of patients who...

  • Alcohol Misuse Prevalence and Associations with Post-Operative Complications in US Surgical Patients: A Review. Harris, Alex H. S.; Frey, Madeleine S.; DeBenedetti, Anna F.; Bradley, Katharine A. // Open Surgery Journal;2008, Vol. 2, p50 

    We conducted a standardized review of research on the prevalence of alcohol use or misuse (including alcohol use disorders), and the association of alcohol use or misuse with post-operative surgical complications among US patients. Twenty seven studies that included a preoperative measure of...

  • Robot-assisted thoracic surgery versus open thoracic surgery for lung cancer: a system review and meta-analysis. Liangze Zhang; Shugeng Gao // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 10, p17804 

    The aim of this meta-analysis is to compare the perioperative morbidity and mortality outcomes of roboticassisted thoracic surgery (RATS) with open thoracic surgery (OTS) for patients with lung cancer. We searched articles indexed in the Pubmed and Sciencedirect published as of July 2015 that...

  • GI Complications After Orthotopic Lung Transplantation. Lubetkin, Erica I.; Lipson, David A.; Palevsky, Harold I.; Kotloff, Robert; Morris, Jon; Berry, Gerard T.; Tino, Gregory; Rosato, Ernest F.; Berlin, Jesse A.; Wurster, Angela B.; Kaiser, Larry R.; Lichtenstein, Gary R. // American Journal of Gastroenterology;Nov1996, Vol. 91 Issue 11, p2382 

    Objectives: Recently, Lung transplantation has been performed with increasing frequency and improved outcomes. GI complications have been observed and reported in patients undergoing cardiac and renal transplantations but only recently have been reported in patients after lung transplantation....

  • Analysis of surgical and perioperative complications in seventy-five right hepatectomies for living donor liver transplantation. Gruttadauria, Salvatore; Marsh, James Wallis; Vizzini, Giovan Battista; Di Francesco, Fabrizio; Luca, Angelo; Volpes, Riccardo; Marcos, Amadeo; Gridelli, Bruno; Martins, Paulo Ney Aguiar; Testro, Adam G. // World Journal of Gastroenterology;5/28/2008, Vol. 14 Issue 20, p3159 

    AIM: To present an analysis of the surgical and perioperative complications in a series of seventy-five right hepatectomies for living-donation (RHLD) performed in our center. METHODS: From January 2002 to September 2007, we performed 75 RHLD, defined as removal of a portion of the liver...

  • Transmission of glioblastoma multiforme following bilateral lung transplantation from an affected donor: Case study and review of the literature. Armanios, Mary Y.; Grossman, Stuart A.; Yang, Stephen C.; White, Barbara; Perry, Arie; Burger, Peter C.; Orens, Jonathan B. // Neuro-Oncology;Jul2004, Vol. 6 Issue 3, p259 

    Donor-acquired solid organ malignancy is a rare complication of organ transplan-tation. We report a case of a patient who received bilateral lung transplants for pulmonary fibrosis from a donor with known glioblastoma multiforme (GBM). The lungs, heart, liver, and kidneys were harvested after a...

  • Neoadjuvant Chemotherapy for Non-Small-Cell Lung Cancer: Does It Really Impact on Postoperative Outcome After Lung Resection? Voltolini, L.; Rapicetta, C.; Ligabue, T.; Scolletta, S.; Ghiribelli, C.; Gotti, G. // European Journal of Clinical & Medical Oncology;2011, Vol. 3 Issue 2, p57 

    BACKGROUND Although some studies seem to indicate a positive prognostic value of induction chemotherapy in patients with locally advanced Non-Small-Cell Lung Cancer (NSCLC), its impact on postoperative mortality and morbidity is not well established. MATERIALS AND METHODS We reviewed the records...

  • Is it safe to include octogenarians at the start of a video-assisted thoracic surgery lobectomy programme?†. Amer, Khalid; Khan, Ali-Zamir; Vohra, Hunaid; Saad, Rasheed // European Journal of Cardio-Thoracic Surgery;Feb2012, Vol. 41 Issue 2, p346 

    OBJECTIVE The study aimed to investigate the safety of including patients ≥80 years of age at the start of a video-assisted thoracic surgery major pulmonary resection (VMPR) programme. METHODS Patients were considered for VMPR if the computed tomography/positron emission tomography...

  • Benchmarking in thoracic surgery Freixinet, Jorge L.; Varela, Gonzalo; Molins, Laureano; Rivas, Juan J.; Rodríguez-Paniagua, José M.; de Castro, Pedro López; Izquierdo, José M.; Torres, Juan // European Journal of Cardio-Thoracic Surgery;Jul2011, Vol. 40 Issue 1, p124 

    Abstract: Objective: Presentation of an experience in benchmarking in 13 university Spanish thoracic surgery services. Methods: The minimum basic data set (MBDS) for hospitalization, corresponding to 2007, including all registered hospital discharges, was used. The performance of the hospitals...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics