Abhishek De; Rao, Raghavendra; Balachandran, C.
October 2010
Indian Journal of Dermatology;Oct-Dec2010, Vol. 55 Issue 4, p334
Academic Journal
Background: Direct immunofluorescence (DIF) is the gold standard in the diagnosis of immunobullous diseases. However, it cannot reliably differentiate various subtypes of subepidermal immune- bullous diseases (SIBD). Salt split technique (SST) could be used under such circumstances to differentiate them. There is paucity of reports in the Indian literature regarding the SST. Aim: This study was designed to evaluate the utility of direct SST in subepidermal blistering diseases. Materials and Methods: Fourteen clinically diagnosed cases of subepidermal blistering diseases were included in the study. Two perilesional punch biopsies were taken one each for DIF and salt split study. Results: Linear basement membrane zone band with IgG and/or C3 was seen in 14 cases of patients BP. Salt split study showed epidermal or mixed pattern of deposits in 12 patients and exclusive floor pattern in two patients. The diagnosis was revised in these two patients to epidermolysis bullosa acquisita. Conclusion: SST is a simple, inexpensive procedure and should be routinely employed in the diagnosis of subepidermal bullous diseases.


Related Articles

  • Education: Pictorial Case Study. Watkins, Jean // GP: General Practitioner;11/13/2009, p47 

    The article presents a case study of an old man with bullous pemphigoid on his skin. He had consumed an oral antihistamine to treat his itchy skin, but that did not benefit him much, as few days later blisters filled with blood-stained fluid appeared on his trunk, thighs, and arms. The doctor...

  • Blisters on an elderly woman's toes. Mims, Lisa; Savage, Alice; Chessman, Alexander; Usatine, Richard P. // Journal of Family Practice;May2014, Vol. 63 Issue 5, p273 

    The article presents a case study of a 69-year-old woman, with a history of hyperlipidelia, hypertension and diabetes, has been brought to the emergency department (ED) due to blisters in her toes and that has been suspected for having cellulitis. It states that the woman has been diagnosed of...

  • Blisters on the with darkened urine hands of a man. Yang, Deborah // Cortlandt Forum;Dec2006, Vol. 19 Issue 12, p85 

    A quiz concerning the diagnosis of a 45-year-old man with blisters is presented.

  • Accurately Diagnosing Commonly Misdiagnosed Circular Rashes. Popovich, Debbie; McAlhany, Allison // Dermatology Nursing;Aug2008, Vol. 20 Issue 4, p294 

    The article offers accurate diagnosing of commonly misdiagnosed circular rashes. It is reported that rashes are common in the pediatric population but can be difficult to diagnose. Four cases involving these rashes are presented including Granuloma annulare and Bullous Impetigo. Symptoms are...

  • Diabetic dermopathy ("shin spots") and diabetic bullae ("bullosis diabeticorum") at the same patient. Brzezinski, Piotr; Chiriac, Anca E.; Pinteala, Tudor; Foia, Liliana; Chiriac, Anca // Pakistan Journal of Medical Sciences;Sep/Oct2015, Vol. 31 Issue 5, p1 

    We present a diabetic patient with associated two diabetic dermatoses: diabetic dermopathy ("shin spots") and diabetic bullae. A 34-year-old man, with long history of diabetes mellitus, hypertension, and moderate obesity presented to Dermatology Unit for diagnosis of his skin lesions. On...

  • Atrophic rash in a patient with hepatitis C. McGevna, Laura; Nelson, Robert Scott // Clinical Advisor;Mar2010, Vol. 13 Issue 3, p75 

    The article presents a case study of a 44-year-old Caucasian man with a history of alcohol abuse and hepatitis C. It notes that the patients has been developing purplish plaques on his face, anterior and posterior trunk. The plaques had initially manifested as tense vesicles and bullae and...

  • Isolated HSV-2 on the Helix Manifesting as a Single Large Vesicle in a Healthy Woman. Scheinfeld, Noah // Acta Dermato-Venereologica;Sep2003, Vol. 83 Issue 5, p378 

    Examines the cause of a blister in the middle of right helix of the 56-year-old female patient. Past medical history of the patient as of September 1, 2003; Details of physical examination of the blister; Treatment regimen of the patient; Revelation that the patient was suffering from herpes...

  • Treating bullous pemphigoid. Frost, Tessa // Independent Nurse;4/7/2008, p25 

    The article offers information on how to manage bullous pemphigoid, a relatively common blistering disorder seen predominantly in the elderly. According to the author, this blistering disorder require care management with the help of topical or systematic steroids as the mainstray of its...

  • Angina Bullosa Hemorrhagica: Report of Two Cases. Rai, Shalu; Kaur, Mandeep; Goel, Sumit // Indian Journal of Dermatology;Nov/Dec2012, Vol. 57 Issue 6, following p502 

    Angina bullosa hemorrhagic (ABH) describes the acute and sometimes painful onset of oral blood-filled vesicles and bullae, not attributable to blood dyscrasia, vesiculobullous disorders, systemic diseases or other known causes. The haemorrhagic bullae spontaneously burst after a short time...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics