Abidi, Afroz; Ahmad, Farida; Singh, Satyendra K.; Kumar, Anil
October 2010
Indian Journal of Dermatology;Oct-Dec2010, Vol. 55 Issue 4, p329
Academic Journal
Background: Topical corticosteroids used in various dermatological diseases several times a day led to an increase risk of side effects. By demonstrating a significant reservoir of corticosteroids in the stratum corneum, one can maximize their efficacy and safety as therapeutic agents. Aim: The study was designed to demonstrate a reservoir of topically applied corticosteroid clobetasol propionate cream experimentally in rabbits using histamine-induced wheal suppression test. Materials and Methods: The work was carried out on albino rabbits, as rabbit skin is akin to human skin, using a topical steroid. The topical steroid clobetasol propionate 0.05% cream was applied on the back of rabbit, and after 1-h occlusion histamine-induced wheal suppression test was performed and wheal area measured at 10 min till day 7. Statistical analysis was done by ANOVA followed by "Post Hoc" test. Results: Maximum wheal suppression was seen on day 1 (P < 0.001). Interday comparison of mean wheal size showed no significant difference (P > 0.05) on day 2, 3, and 4 as compared to day 1. Day 5-7 show highly significant difference (P < 0.001) as compared to day 1, thereby suggesting that the reservoir effect of topical clobetasol propionate 0.05% cream persisted till day 4. Conclusions: This work demonstrated that histamine-induced wheal by the topical steroid clobetasol propionate 0.05% cream was suppressed till day 4, indicating that the reservoir of topical corticosteroid persisted till day 4.


Related Articles

  • Clavulanic acid.  // Reactions Weekly;1/31/2009, Issue 1237, p9 

    The article describes the case of a 35-year-old female nurse who presented with pruritic, erythematous patches affecting both her hands and forearms two days after coming into contact with amoxicillin/clavulanic acid dry syrup. She was given oral antihistamines and topical corticosteroids, and...

  • Time course of action of two inhaled corticosteroids, fluticasone propionate and budesonide. Phillips K; Oborne J; Lewis S; Harrison T W; Tattersfield A E // Thorax;Jan2004, Vol. 59 Issue 1, p26 

    BACKGROUND: It is important to be able to compare the efficacy and systemic effects of inhaled corticosteroids but their slow onset of action makes it difficult to measure the maximum response to a given dose. Submaximal responses could be compared if the time course of action of the inhaled...

  • Generalized Pustular Psoriasis on Withdrawal of Clobetasol Propionate Ointment. Boxley, J.D.; Dawber, R.P.R.; Summerly, R. // British Medical Journal;5/3/1975, Vol. 2 Issue 5965, p255 

    Examines the treatment of generalized pustular psoriasis from chronic psoriasis in Great Britain. Efficacy of withdrawal of systemic corticosteroid treatment; Occurrence of rebound effect on reduction or withdrawal of use; Application of clobetasol propionate ointment.

  • Abatacept for relapsing polychondritis. Moulis, Guillaume; Sailler, Laurent; Astudillo, Leonardo; Arlet, Philippe // Rheumatology;May2010, Vol. 49 Issue 5, p1019 

    The article discusses the effectiveness of abatacept for relapsing polychondritis (RP). A case study of a 49-year-old woman with febrile chondritis in both ears, nose and larynx is presented. The first line of treatment for RP are corticosteroids such as non-steroidal anti-inflammatory drugs...

  • Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: meta-analysis. Peter, John Victor; John, Preeta; Graham, Petra L.; Moran, John L.; George, Ige Abraham; Bersten, Andrew // BMJ: British Medical Journal (International Edition);5/3/2008, Vol. 336 Issue 7651, p1006 

    Objective To systematically review the efficacy of steroids in the prevention of acute respiratory distress syndrome (ARDS) in critically ill adults, and in treatment for established ARDS. Data sources Search of randomised controlled trials (1966-April 2007) of PubMed, Cochrane central...

  • How Important is Onset of Action in Ulcerative Colitis Therapy? Masson, Steven; Nylander, David; Mansfield, John C. // Drugs;2005, Vol. 65 Issue 15, p2069 

    Pharmacotherapy is the cornerstone of management in ulcerative colitis. However, controversy remains over optimal medical strategies. Specifically, differences in the onset of action of various drug therapies are thought to influence the achievement and maintenance of remission of disease, yet...

  • Population Pharmacokinetic/Pharmacodynamic Modeling of Systemic Corticosteroid Inhibition of Whole Blood Lymphocytes: Modeling Interoccasion Pharmacodynamic Variability. Ying Hong; Donald Mager; Robert Blum; William Jusko // Pharmaceutical Research;Jun2007, Vol. 24 Issue 6, p1088 

    Abstract Purpose  To develop a population pharmacokinetic/pharmacodynamic (PK/PD) model that characterizes the effects of major systemic corticosteroids on lymphocyte trafficking and responsiveness. Materials and Methods  Single, presumably equivalent, doses of...

  • Allopurinol.  // Reactions Weekly;5/3/2008, Issue 1200, p8 

    The article describes the case of an old man who developed drug rash with eosinophilia and systemic symptoms (DRESS) syndrome during treatment with allopurinol. It was suspected that the patient had a hypersensitivity reaction to allopurinol. The man received oral antihistamines following the...

  • Corticosteroids and antibiotics for management of PROM. Walling, Anne D. // American Family Physician;4/1/1997, Vol. 55 Issue 5, p1960 

    States that Lewis and colleagues studied the effectiveness of corticosteroids and antibiotics in the management of preterm premature rupture of the membranes (PROM). Method used in the study; How the patients who did not receive corticosteroids had higher rates of gravity than the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics