TITLE

Rapid determination of levofloxacin in pharmaceuticals and biological fluids using a new chemiluminescence system

AUTHOR(S)
Xiaodong Shao; Ying Li; Yangqin Liu; Zhenghua Song
PUB. DATE
January 2011
SOURCE
Journal of Analytical Chemistry;Jan2011, Vol. 66 Issue 1, p102
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
novel chemiluminescence method for the determination of levofloxacin is presented, which is based on the inhibitory effect of levofloxacin on the chemiluminescence reaction between luminol and myoglobin in a flow-injection system. The decrement of chemiluminescence intensity is linear with the logarithm of levofloxacin concentration over the range from 0.07 to 100.0 ng/mL ( r = 0.9994), with the detection limit of 0.02 ng/mL (3s). At a flow rate of 2.0 mL/min, a complete analytical process could be performed within 0.5 min, including sampling and washing, with a relative standard deviation of less than 3.0% ( n = 5). The proposed procedure was applied successfully to the determination of levofloxacin in pharmaceutical preparations, human urine and serum without any pretreatment procedure.
ACCESSION #
57241939

 

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