Oak, Green Tea and Orange Derivatives to Disrupt JAK/STAT, NF-κB Irritation Pathways

DellAcqua, Giorgio; Schweikert, Kuno; Calloni, Giuseppe
January 2011
Cosmetics & Toiletries;Jan2011, Vol. 126 Issue 1, p30
Activation of NF-κB and JAK/STAT pathways in keratinocytes leads to the release of immunomodulating factors that sustain an amplification loop between the keratinocyte and infiltrating immune cell, leading to skin irritation. To disrupt this loop, two complexes, one based on oak and green tea extracts, and another on orange flavonoids, were developed and are shown here to immediately soothe skin.


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