TITLE

Experimental Studies on Guinea Pig Regarding the Influence of Polyunsaturated Fatty Acids as Enhancer in Statin Medication

AUTHOR(S)
Mihaiu, Marian; Tăulescu, Carmen; Miclăuş, Viorel; Dan, Sorin Daniel; Mihaiu, Romolica; Lapuşan, Alexandrea; Ioana^Corbeanu, Crina; Mihaiu, Liora Mihaela; Ciupa, Ana
PUB. DATE
July 2010
SOURCE
Bulletin of the University of Agricultural Sciences & Veterinary;2010, Vol. 67 Issue 2, p150
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract. Although statin therapy is the standard intervention for lowering LDL cholesterol, combination therapy may add benefits on secondary lipid parameters and enhances statin-mediated reductions in LDL cholesterol. The present study was undertaken to investigate the effect of statins plus omega-3 polyunsaturated fatty acids (PUFAs) on endothelial function and lipid profile in guinea pigs with dyslipidemia and endothelial lesions. We used 14 Guinea pigs (12 weeks old) fed with a diet containing 0,5 % cholesterol for 12 weeks and randomized in two groups: Crestor&Omacor (0,6 mg/kg rosuvastatin and 571.4 mg/kg omega-3 PUFAs) and Crestor (0,6 mg/kg rosuvastatin). Compared to Crestor group, Omega-3 PUFAs plus rosuvastatin improved the lipid profile (triglycerides from 94 mg/dl to 84 mg/dl and HDL cholesterol from 11 mg/dl to 23 mg/dl) and the proportion between serum lipoprotein. Endothelial lesions were noticed in both Crestor and Crestor&Omacor groups due to simultaneous adding of cholesterol in diet, but without observing any difference between the two groups. Combined therapy with omega-3-PUFAs and rosuvastatin improves lipid profile but not endothelial lesions in guinea pigs.
ACCESSION #
57208168

 

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