Experimental Studies on Guinea Pig Regarding the Influence of Polyunsaturated Fatty Acids as Enhancer in Statin Medication

Mihaiu, Marian; Tăulescu, Carmen; Miclăuş, Viorel; Dan, Sorin Daniel; Mihaiu, Romolica; Lapuşan, Alexandrea; Ioana^Corbeanu, Crina; Mihaiu, Liora Mihaela; Ciupa, Ana
July 2010
Bulletin of the University of Agricultural Sciences & Veterinary;2010, Vol. 67 Issue 2, p150
Academic Journal
Abstract. Although statin therapy is the standard intervention for lowering LDL cholesterol, combination therapy may add benefits on secondary lipid parameters and enhances statin-mediated reductions in LDL cholesterol. The present study was undertaken to investigate the effect of statins plus omega-3 polyunsaturated fatty acids (PUFAs) on endothelial function and lipid profile in guinea pigs with dyslipidemia and endothelial lesions. We used 14 Guinea pigs (12 weeks old) fed with a diet containing 0,5 % cholesterol for 12 weeks and randomized in two groups: Crestor&Omacor (0,6 mg/kg rosuvastatin and 571.4 mg/kg omega-3 PUFAs) and Crestor (0,6 mg/kg rosuvastatin). Compared to Crestor group, Omega-3 PUFAs plus rosuvastatin improved the lipid profile (triglycerides from 94 mg/dl to 84 mg/dl and HDL cholesterol from 11 mg/dl to 23 mg/dl) and the proportion between serum lipoprotein. Endothelial lesions were noticed in both Crestor and Crestor&Omacor groups due to simultaneous adding of cholesterol in diet, but without observing any difference between the two groups. Combined therapy with omega-3-PUFAs and rosuvastatin improves lipid profile but not endothelial lesions in guinea pigs.


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