Use of extracorporeal life support to support patients with acute respiratory distress syndrome due to H1N1/2009 influenza and other respiratory infections

Wong, Ivan; Vuylsteke, Alain
January 2011
Perfusion;Jan2011, Vol. 26 Issue 1, p7
Academic Journal
A large proportion of critically ill H1N1/2009 patients with respiratory failure subsequently developed ARDS and, to date, about 400 patients receiving extracorporeal life support (ECLS) have been accounted for globally, with a reported survival rate from 63% to 79%. The survival rates of patients with ARDS due to non-H1N1/2009 infections are similar. There is no definite evidence to suggest that patient outcomes are changed by ECLS, but its use is associated with serious short-term complications.ECLS relies on an extracorporeal circuit, with extracorporeal membrane oxygenation (ECMO) and pumpless interventional lung assist (ILA) being the two major types employed in ARDS. Both have the potential to correct respiratory failure and related haemodynamic instability. There are only a very limited number of clinical trials to test either and, although ECLS has been used in treating H1N1/2009 patients with ARDS with some success, it should only be offered in the context of clinical trials and in experienced centres.


Related Articles

  • Referral to an Extracorporeal Membrane Oxygenation Center and Mortality Among Patients With Severe 2009 Influenza A(H1N1). Noah, Moronke A.; Peek, Giles J.; Finney, Simon J.; Griffiths, Mark J.; Harrison, David A.; Grieve, Richard; Sadique, M. Zia; Sekhon, Jasjeet S.; McAuley, Daniel F.; Firmin, Richard K.; Harvey, Christopher; Cordingley, Jeremy J.; Price, Susanna; Vuylsteke, Alain; Jenkins, David P.; Noble, David W.; Bloomfield, Roxanna; Walsh, Timothy S.; Perkins, Gavin D.; Menon, David // JAMA: Journal of the American Medical Association;10/19/2011, Vol. 306 Issue 15, p1659 

    The article discusses a study which compared the mortality of hospital patients with Influenza A (H1N1)-related acute respiratory distress syndrome (ARDS) referred to extracorporeal membrane oxygenation (ECMO) centers with patients having the same condition but were not referred for ECMO in...

  • Extracorporeal Membrane Oxygenation as a First-Line Treatment Strategy for ARDS: Is the Evidence Sufficiently Strong? Checkley, William // JAMA: Journal of the American Medical Association;10/19/2011, Vol. 306 Issue 15, p1703 

    The author looks at the use of extracorporeal membrane oxygenation (ECMO) as early treatment for acute respiratory distress syndrome (ARDS). He references a study by M. A. Noah et al. published within the issue. He cites that the study suggests that the use of ECMO can be immediately established...

  • Extracorporeal membrane oxygenation for 2009 influenza A(H1N1) severe respiratory failure in Japan. Takeda, Shinhiro; Kotani, Toru; Nakagawa, Satoshi; Ichiba, Shingo; Aokage, Toshiyuki; Ochiai, Ryoichi; Taenaka, Nobuyuki; Kawamae, Kaneyuki; Nishimura, Masaji; Ujike, Yoshihito; Tajimi, Kimitaka // Journal of Anesthesia;2012, Vol. 26 Issue 5, p650 

    Purpose: To evaluate procedures and outcomes of extracorporeal membrane oxygenation (ECMO) therapy applied to 2009 influenza A(H1N1) severe respiratory failure patients in Japan. Methods: This observational study used database information about adults who received ECMO therapy for H1N1-related...

  • ECMO criteria for influenza A (H1N1)-associated ARDS: role of transpulmonary pressure. Grasso, Salvatore; Terragni, Pierpaolo; Birocco, Alberto; Urbino, Rosario; Sorbo, Lorenzo; Filippini, Claudia; Mascia, Luciana; Pesenti, Antonio; Zangrillo, Alberto; Gattinoni, Luciano; Ranieri, V. // Intensive Care Medicine;Mar2012, Vol. 38 Issue 3, p395 

    Purpose: To assess whether partitioning the elastance of the respiratory system ( E) between lung ( E) and chest wall ( E) elastance in order to target values of end-inspiratory transpulmonary pressure (PPLAT) close to its upper physiological limit (25 cmHO) may optimize oxygenation allowing...

  • Extracorporeal membrane oxygenation for severe influenza A (H1N1) acute respiratory distress syndrome: a prospective observational comparative study. Roch, Antoine; Lepaul-Ercole, Renaud; Grisoli, Dominique; Bessereau, Jacques; Brissy, Olivier; Castanier, Matthias; Dizier, Stephanie; Forel, Jean-Marie; Guervilly, Christophe; Gariboldi, Vlad; Collart, Frederic; Michelet, Pierre; Perrin, Gilles; Charrel, Remi; Papazian, Laurent // Intensive Care Medicine;Nov2010, Vol. 36 Issue 11, p1899 

    Purpose: To compare characteristics, clinical evolution and outcome in adult patients with influenza A (H1N1) acute respiratory distress syndrome (ARDS) treated with or without extracorporeal membrane oxygenation (ECMO). Methods: A prospective observational study of patients treated in Marseille...

  • Plasma Concentrations of Oseltamivir and Oseltamivir Carboxylate in Critically Ill Children on Extracorporeal Membrane Oxygenation Support. Wildschut, Enno D.; de Hoog, Matthijs; Ahsman, Maurice J.; Tibboel, Dick; Osterhaus, Albert D. M. E.; Fraaij, Pieter L. A. // PLoS ONE;2010, Vol. 5 Issue 6, p1 

    Introduction: To evaluate the effect of extracorporeal membrane oxygenation (ECMO) support on pharmacokinetics of oseltamivir and oseltamivir carboxylate (OC) in children. Methodology: Steady state 0-12 hour pharmacokinetic sampling was performed in new influenza A (H1N1) infected children...

  • Extracorporeal Membrane Oxygenation for ARDS Due to 2009 Influenza A(H1N1). Laudi, Sven; Busch, Thilo; Kaisers, Udo; Freebairn, Ross; McHugh, Gerard; Hickling, Keith; Davies, Andrew; Jones, Daryl; Gattas, David // JAMA: Journal of the American Medical Association;3/10/2010, Vol. 303 Issue 10, p941 

    Several letters to the editor are presented in response to the article "Extracorporeal Membrane Oxygenation for 2009 Influenza A (H1N1) Acute Respiratory Distress Syndrome," by A. Davies and colleagues, published in the 2009 issue, including the utilization of extracorporeal membrane oxygenation...

  • Impact of H1N1 on Socially Disadvantaged Populations: Systematic Review. Tricco, Andrea C.; Lillie, Erin; Soobiah, Charlene; Perrier, Laure; Straus, Sharon E. // PLoS ONE;Jun2012, Vol. 7 Issue 6, p1 

    Background: The burden of H1N1 among socially disadvantaged populations is unclear. We aimed to synthesize hospitalization, severe illness, and mortality data associated with pandemic A/H1N1/2009 among socially disadvantaged populations. Methods/Principal Findings: Studies were identified...

  • Retrieval of critically ill adults using extracorporeal membrane oxygenation: an Australian experience. Forrest, P.; Ratchford, J.; Burns, B.; Herkes, R.; Jackson, A.; Plunkett, B.; Torzillo, P.; Nair, P.; Granger, E.; Wilson, M.; Pye, R. // Intensive Care Medicine;May2011, Vol. 37 Issue 5, p824 

    Purpose: A retrieval program was developed in New South Wales (NSW), Australia to provide extracorporeal membrane oxygenation support (ECMO) for the safe transport of adults with severe, acute respiratory or cardiac failure. We describe the development and results of this program and the impact...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics