Editorial: Viral Factors and Outcomes of Chronic HBV Infection

Yuehua Huang; Lok, Anna S. F.
January 2011
American Journal of Gastroenterology;Jan2011, Vol. 106 Issue 1, p93
Academic Journal
Viral factors associated with outcome of chronic hepatitis B virus (HBV) infection include hepatitis B e antigen status, HBV DNA, genotype, and HBV variants. Mutations in the HBV core promoter region have been shown to be independently associated with hepatocellular carcinoma (HCC). The most common core promoter mutations involve a double substitution A1762T and G1764A (TA). Besides TA mutations, several other core promoter changes have been reported to be associated with the development of cirrhosis and HCC. Future studies should determine if detection of these changes can predict the outcome of patients with chronic HBV infection.


Related Articles

  • Relationship between the Development of Precore and Core Promoter Mutations and Hepatitis B e Antigen Seroconversion in Patients with Chronic Hepatitis B Virus. Man-Fung Yuen; Sablon, Erwin; He-Jun Yuan; Chee-Kin Hui; Wong, Danny Ka-Ho; Doutreloigne, Joke; Wong, Benjamin Chun-Yu; Chan, Annie On-On; Ching-Lung Lai // Journal of Infectious Diseases;11/1/2002, Vol. 186 Issue 9, p1335 

    Chinese patients with chronic hepatitis B virus (332 with and 44 without cirrhosis-related complications) were studied. Fifty percent of patients <30 years old had precore mutations. The prevalence of precore mutations among hepatitis B e antigen (HBeAg)-positive patients, although lower than...

  • Gut microbiota modulate the immune effect against hepatitis B virus infection. Xu, D.; Huang, Y.; Wang, J. // European Journal of Clinical Microbiology & Infectious Diseases;Nov2015, Vol. 34 Issue 11, p2139 

    The immunological mechanisms by which hepatitis B virus (HBV) initiates and maintains acute or chronic infection, even the formation of cirrhosis and hepatocellular carcinoma, are still undefined. An increasing number of studies have shown that intestinal flora regulate immune homeostasis, and,...

  • Mutations in the S gene region of hepatitis B virus genotype D in Turkish patients. Özaslan, Mehmet; Özaslan, Ersan; Barsgan, Arzu; Koruk, Mehmet // Journal of Genetics;Dec2007, Vol. 86 Issue 3, p195 

    The S gene region of the hepatitis B virus (HBV) is responsible for the expression of surface antigens and includes the 'a'-determinant region. Thus, mutation(s) in this region would afford HBV variants a distinct survival advantage, permitting the mutant virus to escape from the immune system....

  • Acute Hepatitis B and C Virus Coinfection: A Virological and Clinical Study of 3 Cases. Coppola, Nicola; Marrocco, Cecilia; Di Caprio, Domenico; Coviello, Giancarlo; Scolastico, Carlo; Filippini, Pietro; Sagnelli, Evangelista // Clinical Infectious Diseases;2/15/2003, Vol. 36 Issue 4, p528 

    We report the virological interaction in, clinical presentation of, and course of disease observed in 3 male injection drug users with acute hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection. In all 3 cases, HBV infection presented first and quickly resolved. Diagnosis of acute...

  • HEPATITIS B IN IMMIGRANT POPULATIONS: BREAKING BARRIERS AND IMPROVING OUTCOMES. Gurakar, Ahmet // Johns Hopkins Advanced Studies in Medicine;Dec2009, Vol. 9 Issue 3, p78 

    The article discusses various reports published within the issue, including one on the life cycle of hepatitis B virus (HPV) and another on the management of chronic HPV infection.

  • CONTINUING EDUCATION TEST.  // Johns Hopkins Advanced Studies in Medicine;Dec2009, Vol. 9 Issue 3, p97 

    A quiz concerning hepatitis B infection is presented.

  • Re-evaluation of the Carcinogenic Significance of Hepatitis B Virus Integration in Hepatocarcinogenesis. Suzhen Jiang; Ziwei Yang; Weijie Li; Xiaojun Li; Yongfeng Wang; Jiangbo Zhang; Chunhui Xu; Pei-Jer Chen; Jinlin Hou; McCrae, Malcolm A.; Xiangmei Chen; Hui Zhuang; Fengmin Lu; Chun-Ming Wong // PLoS ONE;Sep2012, Vol. 7 Issue 9, Special section p1 

    To examine the role of hepatitis B virus (HBV) integration in hepatocarcinogenesis, a systematic comparative study of both tumor and their corresponding non-tumor derived tissue has been conducted in a cohort of 60 HBV associated hepatocellular carcinoma (HCC) patients. By using Alu-polymerase...

  • Hepatitis B Virus infection in HIV-positive population in Brazil: results of a survey in the state of Mato Grosso and a comparative analysis with other regions of Brazil. de Almeida Pereira, Rui Alberto Roldão; Mussi, Aparecida Duarte Hg; de Azevedo e Silva, Vergínia Correa; Dutra^Souto, Francisco José // BMC Infectious Diseases;2006, Vol. 6 Issue 1, p34 

    Background: End-stage liver disease is currently a major concern among HIV-positive individuals due to co-infection with hepatotropic virus. Hepatitis C has been pointed out as a remarkable factor for that. More recently, hepatitis B virus (HBV) infection has also been found to play a role on...

  • HBx Gene Mutations in Hepatitis B Virus and Hepatocellular Carcinoma. M., Anumol Mathew; Kurian, Sumitha C.; Varghese, Atul Philip; Oommen, Seema; G., Manoj // Gastroenterology Research;2014, Vol. 7 Issue 1, p1 

    Hepatocellular carcinoma (HCC) is one of the most prevalent cancers which are found in many Asian and African countries. There are several risk factors that may develop to HCC. Along with several other factors contributing to HCC, hepatitis B virus (HBV) infection also accounts for a major...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics